Nisoldipine and Fluconazole: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Fluconazole
Nisoldipine
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased nisoldipine exposure and an increased risk for nisoldipine toxicity
Interaction Deep Dive
Concomitant use of nisoldipine, a CYP3A4 substrate, with a CYP3A4 inhibitor such as fluconazole should generally be avoided1, as this may increase exposure to the CYP3A4 substrate and increase the risk for toxicity. If concomitant use is required use caution and monitor closely. Fluconazole-mediated enzyme inhibition may persist for 4 to 5 days after discontinuation 2.
Why it happens (mechanism)
Inhibition of CYP3A4-mediated nisoldipine metabolism by fluconazole
Common questions
Can I take Nisoldipine and Fluconazole together?
Increased nisoldipine exposure and an increased risk for nisoldipine toxicity Always confirm with your pharmacist or prescriber before making any change.
How serious is the Nisoldipine and Fluconazole interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
From our Q&A
Real reader questions about these medications, each personally answered by our pharmacist:
Questions for your pharmacist
- Does my dose of Nisoldipine or Fluconazole need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (2)
- Product Information: SULAR(R) extended release oral tablets, nisoldipine extended release oral tablets. Shionogi Pharma, Inc, Atlanta, GA, 2010.
- Product Information: DIFLUCAN(R) oral tablets, suspension, fluconazole oral tablets, suspension. Roerig (per FDA), New York, NY, 2023. DailyMed
Keep reading about Fluconazole
Keep reading about Nisoldipine
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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