Nitroglycerin Spray

15 interactions 500 cited references
Also sold as: Nitrolingual Nitrolingual® Pumpspray NitroMist Nitromist®
About Nitroglycerin Spray

Nitroglycerin spray is used to treat episodes of angina (chest pain) in people who have coronary artery disease (narrowing of the blood vessels that supply blood to the heart). The spray may also be used just before activities that may cause episodes of angina in order to prevent the angina from occurring. Nitroglyceri… Read the full Nitroglycerin Spray drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Avanafil Riociguat Sildenafil Tadalafil Vardenafil Alteplase, Recombinant
5 Contraindicated 4 Major 6 Moderate
All (15) Contraindicated (5) Major (4) Moderate (6)

Contraindicated

Nitroglycerin Spray Avanafil Stendra Potentiation of hypotensive effects Details Nitroglycerin Spray Riociguat Adempas Increased risk of hypotension Details Nitroglycerin Spray Sildenafil Liqrev Potentiation of hypotensive effects Details Nitroglycerin Spray Tadalafil Adcirca Increased hypotensive effects of nitrates Details Nitroglycerin Spray Vardenafil Levitra Potentiation of hypotensive effects Details

Major

Nitroglycerin Spray Alteplase, Recombinant Activase Less coronary artery reperfusion, longer time to reperfusion, and more coronary artery reocclusion Details Nitroglycerin Spray Articaine An increased risk of methemoglobinemia Details Nitroglycerin Spray Heparin A decrease in partial thromboplastin time Details Nitroglycerin Spray Lidocaine Akten An increased risk of methemoglobinemia Details

Moderate

Nitroglycerin Spray Acetylcysteine Acetadote Enhanced hypotension and nitroglycerin-induced headache Details Nitroglycerin Spray Apomorphine Apokyn An increased risk of hypotension Details Nitroglycerin Spray Aspirin Acuprin® An increase in nitroglycerin concentrations and additive platelet function depression Details Nitroglycerin Spray Dihydroergotamine Brekiya Dihydroergotamine toxicity (peripheral ischemia, paresthesias, nausea, vomiting) Details Nitroglycerin Spray Nitric Oxide An increased risk of methemoglobinemia Details Nitroglycerin Spray Pancuronium An increase in pancuronium duration of action Details

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