Nitroglycerin Spray and Pancuronium: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Nitroglycerin Spray
Pancuronium
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
An increase in pancuronium duration of action
Interaction Deep Dive
In a case report, nitroglycerin infusion prolonged the pharmacological action of pancuronium. The mechanism of this interaction was not described1.
Why it happens (mechanism)
Possible additive
Common questions
Can I take Nitroglycerin Spray and Pancuronium together?
An increase in pancuronium duration of action Always confirm with your pharmacist or prescriber before making any change.
How serious is the Nitroglycerin Spray and Pancuronium interaction?
It is rated moderate. Can be significant — usually manageable with monitoring.
How quickly could this interaction happen?
The documented onset is "delayed". Effects tend to build up gradually over days to weeks.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
Questions for your pharmacist
- Does my dose of Nitroglycerin Spray or Pancuronium need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there anything you'd monitor while I'm on both?
References (1)
- Glisson SN, El-Etr AA, & Lim R: Prolongation of pancuronium-induced neuromuscular blockade by intravenous infusion of nitroglycerin. Anesthesiology 1979; 51:47-49. DOI
Keep reading about Nitroglycerin Spray
Keep reading about Pancuronium
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