Norepinephrine

Name: Norepinephrine Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

10 interactions 1 explained in plain English

Read the full Norepinephrine drug information page

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 8, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Dihydroergotamine Injection Dihydroergotamine Nasal Spray Amitriptyline Digoxin Entacapone Furosemide Injection

2 Contraindicated 8 Major

All (10) Contraindicated (2) Major (8)

Contraindicated

Norepinephrine Dihydroergotamine Injection DHE-45® Injection Increased risk of elevation of blood pressure Details Norepinephrine Dihydroergotamine Nasal Spray Migranal Increased risk of elevation of blood pressure Details

Major

Norepinephrine Amitriptyline Elavil Explained Severe, prolonged hypertension Details Norepinephrine Digoxin Cardoxin® An increased risk of cardiac arrhythmias Details Norepinephrine Entacapone Comtan An increased risk of tachycardia, hypertension, and arrhythmias Details Norepinephrine Furosemide Injection Disal Decreased arterial responsiveness (vasoconstricting effect) to norepinephrine Details Norepinephrine Linezolid Injection Zyvox Increased hypertensive effects Details Norepinephrine Methylergonovine Methergine Additive hypertensive effects Details Norepinephrine Olodaterol Oral Inhalation Striverdi An increased risk of clinically significant cardiovascular effects and fatalities and an increased/potentiated sympathetic effects... Details Norepinephrine Opicapone Ongentys Increased risk of arrhythmias, increased heart rate, and excessive changes in blood pressure Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.