Ombitasvir

15 interactions 1 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Levonorgestrel Levonorgestrel Intrauterine System Lovastatin Omeprazole Cyclosporine Injection Cyclosporine Ophthalmic
3 Contraindicated 8 Major 4 Moderate
All (15) Contraindicated (3) Major (8) Moderate (4)

Contraindicated

Ombitasvir Levonorgestrel After banger An increased risk of ALT elevation Details Ombitasvir Levonorgestrel Intrauterine System Kyleena An increased risk of ALT elevation Details Ombitasvir Lovastatin Altocor® Increased lovastatin exposure and an increased risk of lovastatin-related adverse effects, such as risk of myopathy and rhabdomyol... Details

Major

Ombitasvir Omeprazole Gastrobim Explained Increased ombitasvir concentration and decreased omeprazole concentration Details Ombitasvir Cyclosporine Injection Atopica Increased cycloSPORINE plasma concentrations; increased ombitasvir plasma concentrations Details Ombitasvir Cyclosporine Ophthalmic Cequa Increased cycloSPORINE plasma concentrations; increased ombitasvir plasma concentrations Details Ombitasvir Disopyramide Norpace Increased concentration of the antiarrhythmic agent Details Ombitasvir Flecainide Tambocor® Increased concentration of the antiarrhythmic agent Details Ombitasvir Ketoconazole Topical Extina® Foam Increased ketoconazole plasma concentrations; increased ombitasvir plasma concentrations Details Ombitasvir Metformin Fortamet® Increased risk of lactic acidosis Details Ombitasvir Mexiletine Mexitil® Increased concentration of the antiarrhythmic agent Details

Moderate

Ombitasvir Azilsartan Edarbi Increased angiotensin receptor blocker plasma concentrations and increased risk of hypotension Details Ombitasvir Eprosartan Teveten® Increased angiotensin receptor blocker plasma concentrations and increased risk of hypotension Details Ombitasvir Irbesartan Avapro Increased angiotensin receptor blocker plasma concentrations and increased risk of hypotension Details Ombitasvir Losartan Arbli Increased angiotensin receptor blocker plasma concentrations and increased risk of hypotension Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.