Omeprazole and Ombitasvir: Interaction Details
AI-assisted, pharmacist-reviewed · AI content regenerated Jul 11, 2026 · Source data updated Jul 2, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Omeprazole
Ombitasvir
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
You've been prescribed omeprazole (a stomach acid reducer, like Prilosec) along with ombitasvir (part of a hepatitis C treatment). When these are taken together, two things can happen. The ombitasvir level in your blood may go up, which could mean more side effects. At the same time, your omeprazole may become less effective, so your heartburn or reflux symptoms might not be as well controlled.
Please don't change anything on your own. This is something your care team can manage easily by watching how you feel and adjusting your dose if needed. If your stomach symptoms come back or you feel unwell, just let your pharmacist or doctor know.
Effect: Concurrent use may increase ombitasvir plasma exposure while decreasing omeprazole concentration.
- Direction: Increased ombitasvir levels (watch for adverse events); reduced omeprazole levels (possible loss of acid-suppression efficacy).
- Mechanism: Unknown/unspecified.
- Evidence: Theoretical; onset unspecified; severity rated major.
- Management: Monitor for decreased omeprazole efficacy and consider a dose increase if symptoms are not controlled; avoid omeprazole doses greater than 40 mg/day. Monitor for increased ombitasvir-associated adverse events. Dosing should be individualized by the care team.
What happens
Increased ombitasvir concentration and decreased omeprazole concentration
Interaction Deep Dive
Taking ombitasvir together with omeprazole can raise plasma levels of ombitasvir, while at the same time lowering omeprazole concentrations. Watch for reduced omeprazole effectiveness, and in patients whose symptoms remain poorly controlled, consider raising the dose. Do not administer omeprazole at doses above 40 mg/day1. Also monitor for an increase in adverse events linked to ombitasvir.
Why it happens (mechanism)
Unknown
How to manage this interaction
The good news is your care team can manage this by tailoring your doses and watching how you respond.
- Keep taking both medications exactly as prescribed unless your doctor tells you otherwise.
- Your team may monitor for reduced omeprazole effect (return of heartburn or reflux) and adjust the dose if your symptoms aren't well controlled.
- Omeprazole doses above 40 mg per day are generally avoided while on ombitasvir.
- Your team may also watch more closely for side effects from the ombitasvir.
Tell your pharmacist or prescriber if your stomach symptoms return or you notice new side effects.
Management is individual — confirm any change with your pharmacist or prescriber.
Common questions
Can I take Omeprazole and Ombitasvir together?
Taking omeprazole with ombitasvir may raise ombitasvir levels and weaken omeprazole's acid control, so keep both as prescribed, avoid omeprazole doses above 40 mg/day, and report returning symptoms or new side effects to your care team. Always confirm with your pharmacist or prescriber before making any change.
How serious is the Omeprazole and Ombitasvir interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How is the Omeprazole and Ombitasvir interaction managed?
The good news is your care team can manage this by tailoring your doses and watching how you respond. Keep taking both medications exactly as prescribed unless your doctor tells you otherwise. Your team may monitor for reduced omeprazole effect (return of heartburn or reflux) and adjust the dose if your symptoms aren't well controlled. Omeprazole doses above 40 mg per day are generally avoided whi… Management is individual — always follow your own care team's guidance.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
From our Q&A
Real reader questions about these medications, each personally answered by our pharmacist:
Questions for your pharmacist
- Does my dose of Omeprazole or Ombitasvir need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: VIEKIRA PAK oral tablets, ombitasvir paritaprevir ritonavir oral tablets and dasabuvir oral tablets. AbbVie Inc. (per manufacturer), North Chicago, Il, 2014.
Keep reading about Omeprazole
Keep reading about Ombitasvir
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Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
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