Opicapone and Dopamine: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Opicapone
Dopamine
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased risk of arrhythmias, increased heart rate, and excessive changes in blood pressure
Interaction Deep Dive
Concomitant use of opicapone (a catechol-o-methyltransferase [COMT] inhibitor) and drugs metabolized by COMT (isoproterenol, epinephrine, norepinephrine, dopamine, and dobutamine), regardless of the route of administration, including inhalation may result in arrhythmias, increased heart rate, and excessive changes in blood pressure. If coadministered, use with caution and monitoring is recommended1.
Why it happens (mechanism)
Inhibition of catecholamine metabolism
Common questions
Can I take Opicapone and Dopamine together?
Increased risk of arrhythmias, increased heart rate, and excessive changes in blood pressure Always confirm with your pharmacist or prescriber before making any change.
How serious is the Opicapone and Dopamine interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Opicapone or Dopamine need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: ONGENTYS(R) oral capsules, opicapone oral capsules. Neurocrine Biosciences Inc (per FDA), San Diego, CA, 2020. DailyMed
Keep reading about Opicapone
Keep reading about Dopamine
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Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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