Opicapone

Name: Opicapone Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

13 interactions 10 cited references

Also sold as: Ongentys Ongentys®

About Opicapone

Opicapone is used along with levodopa and carbidopa (Sinemet, Rytary) to treat the end-of-dose 'wearing-off' symptoms of Parkinson's disease. Opicapone is an inhibitor of catechol-O-methyltransferase (COMT). Opicapone helps the levodopa and carbidopa work better by allowing more of it to reach the brain, where it has i… Read the full Opicapone drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Iproniazid Isocarboxazid Nialamide Phenelzine Tranylcypromine Dobutamine

5 Contraindicated 8 Major

All (13) Contraindicated (5) Major (8)

Contraindicated

Opicapone Iproniazid Increased risk of arrhythmias, increased heart rate, and excessive changes in blood pressure Details Opicapone Isocarboxazid Marplan Increased risk of arrhythmias, increased heart rate, and excessive changes in blood pressure Details Opicapone Nialamide Increased risk of arrhythmias, increased heart rate, and excessive changes in blood pressure Details Opicapone Phenelzine Nardil Increased risk of arrhythmias, increased heart rate, and excessive changes in blood pressure Details Opicapone Tranylcypromine Parnate Increased risk of arrhythmias, increased heart rate, and excessive changes in blood pressure Details

Major

Opicapone Dobutamine Increased risk of arrhythmias, increased heart rate, and excessive changes in blood pressure Details Opicapone Dopamine Increased risk of arrhythmias, increased heart rate, and excessive changes in blood pressure Details Opicapone Metoclopramide Injection Gimoti Diminished effectiveness of metoclopramide and the dopaminergic agent Details Opicapone Metoclopramide Nasal Spray Gimoti Diminished effectiveness of metoclopramide and the dopaminergic agent Details Opicapone Epinephrine Increased risk of arrhythmias, increased heart rate, and excessive changes in blood pressure Details Opicapone Isoproterenol Increased risk of arrhythmias, increased heart rate, and excessive changes in blood pressure Details Opicapone Metoclopramide Diminished effectiveness of metoclopramide and the dopaminergic agent Details Opicapone Norepinephrine Increased risk of arrhythmias, increased heart rate, and excessive changes in blood pressure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.