Drug Interaction Report

Oxycodone and Abiraterone: Interaction Details

A pharmacist-reviewed analysis of the Oxycodone and Abiraterone interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Oxycodone

Oxaydo Oxycontin Roxicodone Roxybond Xtampza
+

Abiraterone

Abirtega Yonsa Zytiga Zytiga®
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
Updated Aug 8, 2026
Editorial policy · Data sources
LinkedIn
Interaction severity
Major
Potentially serious — often needs a change or close monitoring.
How we grade severity & evidence

Severity levels

  • Contraindicated: These should generally not be used together.
  • Major: Potentially serious — often needs a change or close monitoring.
  • Moderate: Can be significant — usually manageable with monitoring.
  • Minor: Usually limited clinical impact.

Evidence grades

  • Established: Well documented — supported by controlled studies or strong clinical data.
  • Probable: Good supporting evidence, though not definitively proven.
  • Suspected: Some evidence suggests this interaction, but it is not well established.
  • Possible: Limited or conflicting evidence; the interaction may occur.
  • Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Of 62 documented Oxycodone interactions, 59 are rated major — including this one.
Worried about symptoms right now? Contact your pharmacist or prescriber, or call Poison Control at 1-800-222-1222 (US). Call 911 for an emergency.
Onset
unspecified
Evidence
theoretical
Severity
Major

What happens

Increased oxyCODONE exposure

Interaction Deep Dive

Abiraterone acetate is a strong CYP2D6 and moderate CYP3A4 inhibitor. In drug interaction studies, the AUC of dextromethorphan (a CYP2D6 substrate) was increased by 2.8-fold1. OxyCODONE is a major substrate of CYP3A4 and is in part metabolized to oxyMORphone via CYP2D6. Coadministration of the CYP3A4 inhibitor voriconazole with oxyCODONE resulted in a 3.6-fold increase in oxyCODONE AUC and a 1.7-fold increase in Cmax. Concomitant use of abiraterone acetate and oxyCODONE may result in prolonged or increased opioid effects. Monitor the patient frequently for respiratory depression or sedation. Consider dose adjustment of oxyCODONE until consistent effects are realized 2, and use caution during therapy and upon initiation and discontinuation 345.

Why it happens (mechanism)

Inhibition of CYP3A4-mediated metabolism of oxyCODONE; inhibition of CYP2D6-mediated metabolism of oxyCODONE

Common questions

Can I take Oxycodone and Abiraterone together?

Increased oxyCODONE exposure Always confirm with your pharmacist or prescriber before making any change.

How serious is the Oxycodone and Abiraterone interaction?

It is rated major. Potentially serious — often needs a change or close monitoring.

How quickly could this interaction happen?

The documented onset is "unspecified". The timing of this interaction is not well characterized.

How strong is the evidence for this interaction?

The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.

Questions for your pharmacist

  • Does my dose of Oxycodone or Abiraterone need adjusting while I take them together?
  • What symptoms should prompt me to call you or my prescriber right away?
  • Does the timing of my doses matter for this combination?
  • Is there a safer alternative to one of these medications for me?

References (5)

  1. Product Information: ZYTIGA(R) oral tablets, abiraterone acetate oral tablets. Janssen Biotech, Inc. (per FDA), Horsham, PA, 2013. DailyMed
  2. Product Information: XARTEMIS(TM) XR oral extended-release tablets, oxycodone HCl acetaminophen oral extended-release tablets. Mallinckrodt Brand Pharmaceuticals, Inc. (per FDA), Hazelwood, MO, 2015.
  3. Product Information: OXAYDO(R) oral tablets, oxycodone HCl oral tablets. Zyla Life Sciences US Inc (per FDA), Wayne, PA, 2021. DailyMed
  4. Product Information: oxycodone HCl oral solution, oxycodone HCl oral solution. Lehigh Valley Technologies, Inc. (per DailyMed), Allentown, PA, 2013. DailyMed
  5. Product Information: OXYCONTIN(R) oral extended-release tablets, oxycodone HCl oral extended-release tablets. Purdue Pharma LP (per FDA), Stamford, CT, 2018. DailyMed
Was this write-up helpful?
Oxycodone

Keep reading about Oxycodone

All Oxycodone interactions (62)
Also serious with: Ketoconazole Topical Lacosamide Injection Midazolam Nasal Spray Buprenorphine
Abiraterone

Keep reading about Abiraterone

All Abiraterone interactions (164) Abiraterone drug information
Also serious with: Ensitrelvir Abametapir Acarbose Albiglutide
Beyond drug–drug

These medications also interact with supplements

Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:

Oxycodone + 1,4-butanediol Activated Charcoal Beer Gamma-hydroxybutyrate (ghb) Kava L-tryptophan St. John's Wort Wine + 137 more
Abiraterone + Activated Charcoal Beer Grapefruit Siberian Cocklebur St. John's Wort Wine Acacia Rigidula Adrafinil + 173 more

major · moderate · minor — check everything you take with our drug–supplement interaction checker.

Check another combination

Our instant two-drug interaction checker is almost here.

Coming soon

The instant two-drug checker is on its way.

In the meantime, browse the directory below to look up any drug and see its documented interactions.

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
This information is for education, not a substitute for professional medical advice. Do not start, stop, or change any medication without talking to your pharmacist or prescriber.