Pazopanib and Fentanyl Transdermal Patch: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Fentanyl Transdermal Patch
Pazopanib
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased fentanyl plasma concentrations and risk of fentanyl toxicity
Interaction Deep Dive
Studies in cancer patients demonstrated that pazopanib was a weak inhibitor of CYP3A4. The concomitant use of agents with a narrow therapeutic range that are metabolized by CYP3A41, such as fentanyl, and pazopanib may increase the concentrations of fentanyl and increase the risk for serious fentanyl-related adverse events. Therefore, the coadministration of these agents is not recommended 1.
Why it happens (mechanism)
Inhibition of CYP3A4-mediated fentanyl metabolism
Common questions
Can I take Pazopanib and Fentanyl Transdermal Patch together?
Increased fentanyl plasma concentrations and risk of fentanyl toxicity Always confirm with your pharmacist or prescriber before making any change.
How serious is the Pazopanib and Fentanyl Transdermal Patch interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Pazopanib or Fentanyl Transdermal Patch need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: VOTRIENT(R) oral tablets, pazopanib oral tablets. GlaxoSmithKline, Research Triangle Park, NC, 2009. DailyMed
Keep reading about Fentanyl Transdermal Patch
Keep reading about Pazopanib
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
Check another combination
Our instant two-drug interaction checker is almost here.
Still have questions about this combination?
Every question gets a real answer from a licensed pharmacist — free, and usually within a day.
Ask the pharmacist