Peginterferon Alfa-2B

Name: Peginterferon Alfa-2B Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

5 interactions 1 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Amitriptyline Anagrelide Doxorubicin Flecainide Mexiletine

5 Major

All (5) Major (5)

Major

Peginterferon Alfa-2B Amitriptyline Elavil Explained Increased plasma concentrations of tricyclic antidepressants metabolized by CYP2D6 and increased risk for toxicities; abrupt toxic... Details Peginterferon Alfa-2B Anagrelide Agrylin Increased plasma concentrations of anagrelide and its active metabolite and increased risk for toxicity including bleeding and QT-... Details Peginterferon Alfa-2B Doxorubicin Adriamycin Increased DOXOrubicin exposure Details Peginterferon Alfa-2B Flecainide Tambocor® Increased exposure CYP2D6 substrate and increased risk for toxicities Details Peginterferon Alfa-2B Mexiletine Mexitil® Increased exposure of the CYP1A2 substrate and increased risk for toxicities Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.