Perindopril

195 interactions 540 cited references
Also sold as: Aceon Aceon® Prestalia® (as a combination product containing Amlodipine, Perindopril)
About Perindopril

Perindopril is an ACE inhibitor medication used to treat high blood pressure. Read the full Perindopril drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Moderate

Perindopril Etozolin Postural hypotension (first dose) Details Perindopril Exenatide Bydureon An increased risk of hypoglycemia Details Perindopril Felbinac Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Perindopril Fepradinol Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Perindopril Feprazone Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Perindopril Floctafenine Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Perindopril Flufenamic Acid Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Perindopril Glyburide DiaBeta® An increased risk of hypoglycemia Details Perindopril Gold Sodium Thiomalate Nitritoid reactions (facial flushing, nausea, vomiting, and hypotension) Details Perindopril Hydrochlorothiazide Inzirqo Reduction of blood pressure Details Perindopril Hydroflumethiazide Reduction of blood pressure Details Perindopril Icatibant Firazyr Reduced perindopril effectiveness Details Perindopril Indapamide Reduction of blood pressure Details Perindopril Indomethacin Indocin Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Perindopril Insulin Afrezza An increased risk of hypoglycemia Details Perindopril Insulin Aspart, Recombinant Fiasp An increased risk of hypoglycemia Details Perindopril Insulin Bovine An increased risk of hypoglycemia Details Perindopril Insulin Degludec Tresiba An increased risk of hypoglycemia Details Perindopril Insulin Detemir Levemir An increased risk of hypoglycemia Details Perindopril Insulin Glargine, Recombinant Basaglar An increased risk of hypoglycemia Details Perindopril Insulin Glulisine Apidra An increased risk of hypoglycemia Details Perindopril Insulin Lispro, Recombinant Admelog An increased risk of hypoglycemia Details Perindopril Lanthanum Carbonate Fosrenol Reduced bioavailability of ACE inhibitors Details Perindopril Liraglutide Saxenda An increased risk of hypoglycemia Details Perindopril Lixisenatide An increased risk of hypoglycemia Details Perindopril Lornoxicam Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Perindopril Loxoprofen Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Perindopril Lumiracoxib Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Perindopril Ma Huang Reduced effectiveness of angiotensin converting enzyme inhibitors Details Perindopril Methyclothiazide Reduction of blood pressure Details Perindopril Metolazone Reduction of blood pressure Details Perindopril Morniflumate Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Perindopril Nepafenac Ilevro Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Perindopril Nesiritide Increase in symptomatic hypotension Details Perindopril Niflumic Acid Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Perindopril Nimesulide Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Perindopril Nimesulide Beta Cyclodextrin Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Perindopril Oxaprozin Coxanto Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Perindopril Oxyphenbutazone Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Perindopril Parecoxib Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details

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