Perindopril

Name: Perindopril Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

195 interactions 540 cited references

Also sold as: Aceon Aceon® Prestalia® (as a combination product containing Amlodipine, Perindopril)

About Perindopril

Perindopril is an ACE inhibitor medication used to treat high blood pressure. Read the full Perindopril drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Aliskiren Valsartan Sacubitril Irbesartan Trimethoprim Melphalan

3 Contraindicated 38 Major 154 Moderate

All (195) Contraindicated (3) Major (38) Moderate (154)

Contraindicated

Perindopril Aliskiren Tekturna An increased risk of hyperkalemia, renal impairment, and hypotension Details Perindopril Sacubitril Increased risk of angioedema Details Perindopril Valsartan Diovan Increased risk of angioedema and an increased risk of adverse events (ie, hypotension, syncope, hyperkalemia, changes in renal fun... Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.