Perindopril

195 interactions 540 cited references
Also sold as: Aceon Aceon® Prestalia® (as a combination product containing Amlodipine, Perindopril)
About Perindopril

Perindopril is an ACE inhibitor medication used to treat high blood pressure. Read the full Perindopril drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Perindopril Aspirin Acuprin® Reduced hyponatremic and hypotensive effects of ACE inhibitors Details Perindopril Aspirin Rectal Aspirin Reduced hyponatremic and hypotensive effects of ACE inhibitors Details Perindopril Azathioprine Azasan Myelosuppression Details Perindopril Azilsartan Edarbi Increased risk of adverse events (ie, hypotension, syncope, hyperkalemia, changes in renal function, acute renal failure) Details Perindopril Cyclosporine Injection Atopica Acute renal dysfunction and an increased risk of hyperkalemia Details Perindopril Cyclosporine Ophthalmic Cequa Acute renal dysfunction and an increased risk of hyperkalemia Details Perindopril Digoxin Cardoxin® An increased digoxin exposure Details Perindopril Eprosartan Teveten® Increased risk of adverse events (ie, hypotension, syncope, hyperkalemia, changes in renal function, acute renal failure) Details Perindopril Everolimus Afinitor Increased risk of angioedema Details Perindopril Furosemide Injection Disal An increased risk of severe hypotension and deterioration in renal function, including renal failure Details Perindopril Irbesartan Avapro Increased risk of adverse events (ie, hypotension, syncope, hyperkalemia, changes in renal function, acute renal failure) Details Perindopril Lithium Carbonate Lithobid Increased risk of lithium toxicity Details Perindopril Losartan Arbli Increased risk of adverse events (ie, hypotension, syncope, hyperkalemia, changes in renal function, acute renal failure) Details Perindopril Melphalan Alkeran An increased risk of severe hypotension Details Perindopril Melphalan Injection Alkeran An increased risk of severe hypotension Details Perindopril Mercaptopurine Purinethol® Myelosuppression Details Perindopril Alteplase, Recombinant Activase An increased risk of orolingual angioedema Details Perindopril Amiloride Increased risk of hyperkalemia Details Perindopril Azilsartan Medoxomil Edarbi Increased risk of adverse events (ie, hypotension, syncope, hyperkalemia, changes in renal function, acute renal failure) Details Perindopril Candesartan Atacand Increased risk of adverse events (ie, hypotension, syncope, hyperkalemia, changes in renal function, acute renal failure) Details Perindopril Canrenoate Increased risk of hyperkalemia Details Perindopril Cyclosporine Atopica Acute renal dysfunction and an increased risk of hyperkalemia Details Perindopril Eplerenone Inspra Increased risk of hyperkalemia Details Perindopril Furosemide Disal An increased risk of severe hypotension and deterioration in renal function, including renal failure Details Perindopril Insulin Icodec-Abae Awiqli An increased risk of hypoglycemia Details Perindopril Lithium Increased risk of lithium toxicity Details Perindopril Olmesartan Benicar Increased risk of adverse events (ie, hypotension, syncope, hyperkalemia, changes in renal function, acute renal failure) Details Perindopril Potassium Glu-K® Hyperkalemia Details Perindopril Potassium Citrate Urocit-K Increased risk of hyperkalemia Details Perindopril Potassium Phosphate K-Phos Increased risk of severe and potentially fatal hyperkalemia Details Perindopril Pregabalin Bonqat Increased risk of angioedema Details Perindopril Sirolimus Felycin Increased risk of angioedema Details Perindopril Spironolactone Aldactone Increased risk of hyperkalemia Details Perindopril Tacrolimus Astagraf An increased risk of hyperkalemia Details Perindopril Telmisartan Micardis Increased risk of adverse events (ie, hypotension, syncope, hyperkalemia, changes in renal function, acute renal failure) Details Perindopril Temsirolimus Torisel Increased risk of angioedema Details Perindopril Triamterene Dyrenium Increased risk of hyperkalemia Details Perindopril Trimethoprim Primsol Increased risk of hyperkalemia Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.