Perindopril

195 interactions 540 cited references

Also sold as: Aceon Aceon® Prestalia® (as a combination product containing Amlodipine, Perindopril)

About Perindopril

Perindopril is an ACE inhibitor medication used to treat high blood pressure. Read the full Perindopril drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Aliskiren Valsartan Sacubitril Irbesartan Trimethoprim Melphalan

3 Contraindicated 38 Major 154 Moderate

All (195) Contraindicated (3) Major (38) Moderate (154)

Moderate

Perindopril Phenylbutazone Equi-Phar Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Perindopril Piketoprofen Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Perindopril Pioglitazone Actos An increased risk of hypoglycemia Details Perindopril Piretanide Postural hypotension (first dose) Details Perindopril Piroxicam Feldene Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Perindopril Polythiazide Reduction of blood pressure Details Perindopril Pramlintide Symlin An increased risk of hypoglycemia Details Perindopril Pranoprofen Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Perindopril Proglumetacin Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Perindopril Propionic Acid Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Perindopril Propyphenazone Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Perindopril Proquazone Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Perindopril Quinethazone Reduction of blood pressure Details Perindopril Repaglinide Prandin® An increased risk of hypoglycemia Details Perindopril Rofecoxib Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Perindopril Rosiglitazone Avandia® An increased risk of hypoglycemia Details Perindopril Salicylic Acid Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Perindopril Salsalate Disalcid Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Perindopril Saxagliptin Onglyza An increased risk of hypoglycemia Details Perindopril Semaglutide Ozempic An increased risk of hypoglycemia Details Perindopril Sitagliptin Brynovin An increased risk of hypoglycemia Details Perindopril Sodium Salicylate Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Perindopril Sulindac Clinoril® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Perindopril Tenoxicam Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Perindopril Tiaprofenic Acid Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Perindopril Tolazamide Tolinase® An increased risk of hypoglycemia Details Perindopril Tolbutamide Orinase® An increased risk of hypoglycemia Details Perindopril Tolfenamic Acid Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Perindopril Tolmetin Tolectin 600 Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Perindopril Torsemide Soaanz Postural hypotension (first dose) Details Perindopril Trichlormethiazide Reduction of blood pressure Details Perindopril Valdecoxib Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Perindopril Xipamide Reduction of blood pressure Details Perindopril Yohimbine Reduced angiotensin converting enzyme inhibitor effectiveness Details

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