Pravastatin

17 interactions 1 explained in plain English
Also sold as: Pravachol Pravachol®
About Pravastatin

Pravastatin is a statin that lowers cholesterol and reduces the risk of heart attack and stroke. Read the full Pravastatin drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Colchicine Bempedoic Acid Colesevelam Cyclosporine Injection Cyclosporine Ophthalmic Daptomycin
12 Major 5 Moderate
All (17) Major (12) Moderate (5)

Major

Pravastatin Colchicine Colcrys Explained An increased risk of myopathy, including rhabdomyolysis Details Pravastatin Bempedoic Acid Nexletol Increased pravastatin exposure and an increased risk of myopathy Details Pravastatin Colesevelam Welchol Reduced exposure to pravastatin Details Pravastatin Cyclosporine Injection Atopica Increased pravastatin exposure and an increased risk of myopathy or rhabdomyolysis Details Pravastatin Cyclosporine Ophthalmic Cequa Increased pravastatin exposure and an increased risk of myopathy or rhabdomyolysis Details Pravastatin Daptomycin Cubicin Increased risk of myopathy or rhabdomyolysis Details Pravastatin Daptomycin Injection Cubicin Increased risk of myopathy or rhabdomyolysis Details Pravastatin Darolutamide Nubeqa Increased exposure of OATP1B1 or OATP1B3 substrates Details Pravastatin Gemfibrozil Lopid Decreased pravastatin clearance, increased pravastatin exposure, and increased risk of myopathy or rhabdomyolysis Details Pravastatin Leniolisib Joenja Increased OATP1B1/OATP1B3 substrate exposure Details Pravastatin Letermovir Injection Prevymis Increased statins exposure and an increased risk for myopathy and rhabdomyolysis Details Pravastatin Midostaurin Rydapt Increased OATP1B1 substrate exposure Details

Moderate

Pravastatin Cholestyramine Resin Locholest® Reduced effectiveness of pravastatin Details Pravastatin Colestipol Colestid Reduced effectiveness of pravastatin Details Pravastatin Encorafenib Braftovi Increased OATP1B1 substrate exposure, increased OATP1B3 substrate exposure, increased risk of OATP1B1 substrate-related toxicities... Details Pravastatin Lanthanum Fosrenol® Reduced statin bioavailability Details Pravastatin Niacin Endur-Acin An increased risk of myopathy and rhabdomyolysis Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.