Pregabalin

31 interactions 3 explained in plain English

Also sold as: Bonqat Lyrica

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Fentanyl Transdermal Patch Lisinopril Perindopril Midazolam Nasal Spray Diazepam Nasal Spray Butorphanol Nasal Spray

30 Major 1 Moderate

All (31) Major (30) Moderate (1)

Major

Pregabalin Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of respiratory depression Details Pregabalin Lisinopril Prinivil Explained Increased risk of angioedema Details Pregabalin Buprenorphine Belbuca Explained An increased risk of respiratory depression Details Pregabalin Aripiprazole Injection Abilify An increased risk of respiratory depression Details Pregabalin Asenapine Transdermal Patch Secuado An increased risk of respiratory depression Details Pregabalin Benazepril Lotensin Increased risk of angioedema Details Pregabalin Butorphanol Injection Butorphic An increased risk of respiratory depression Details Pregabalin Butorphanol Nasal Spray Stadol® NS An increased risk of respiratory depression Details Pregabalin Calcifediol Rayaldee Altered serum levels of calcifediol Details Pregabalin Captopril Capoten® Increased risk of angioedema Details Pregabalin Cetirizine Injection Aller-Tec An increased risk of respiratory depression Details Pregabalin Cetirizine Ophthalmic Zerviate An increased risk of respiratory depression Details Pregabalin Diazepam Nasal Spray Valtoco An increased risk of respiratory depression Details Pregabalin Diazepam Rectal Diastat An increased risk of respiratory depression Details Pregabalin Diphenhydramine Injection Banophen An increased risk of respiratory depression Details Pregabalin Diphenhydramine Topical Afterbite with Antihistamine An increased risk of respiratory depression Details Pregabalin Enalapril Epaned Increased risk of angioedema Details Pregabalin Esketamine Nasal Spray Spravato An increased risk of respiratory depression Details Pregabalin Fentanyl Transdermal Patch Duragesic® An increased risk of respiratory depression Details Pregabalin Fosinopril Monopril® Increased risk of angioedema Details Pregabalin Hydromorphone Injection Dilaudid An increased risk of respiratory depression Details Pregabalin Hydromorphone Rectal available generically An increased risk of respiratory depression Details Pregabalin Hydroxychloroquine Plaquenil Impaired antiepileptic activity Details Pregabalin Midazolam Nasal Spray Nayzilam An increased risk of respiratory depression Details Pregabalin Midazolam Injection Nayzilam An increased risk of respiratory depression Details Pregabalin Moexipril Univasc® Increased risk of angioedema Details Pregabalin Morphine Injection Astramorph® PF An increased risk of respiratory depression Details Pregabalin Nalbuphine Injection Nubain® An increased risk of respiratory depression Details Pregabalin Orlistat Alli Reduced efficacy of anticonvulsant Details Pregabalin Perindopril Aceon Increased risk of angioedema Details

Moderate

Pregabalin Folic Acid Folacin Reduced folic acid exposure and reduced efficacy of folic acid Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.