Probenecid

59 interactions 1 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Injection Ketorolac Ophthalmic Ketorolac Nasal Spray Mesalamine Ketorolac Aspirin Rectal
8 Contraindicated 23 Major 22 Moderate 6 Minor
All (59) Contraindicated (8) Major (23) Moderate (22) Minor (6)

Moderate

Probenecid Acyclovir Avaclyr Increased OAT3 substrate exposure Details Probenecid Acyclovir Injection Avaclyr Increased OAT3 substrate exposure Details Probenecid Acyclovir Ophthalmic Avaclyr Increased OAT3 substrate exposure Details Probenecid Acyclovir Topical Zovirax Increased OAT3 substrate exposure Details Probenecid Cefaclor Ceclor® Increased OAT3 substrate exposure Details Probenecid Cefotaxime Injection Claforan Increased cefotaxime plasma concentrations Details Probenecid Cefpodoxime Banan® Increased serum cefpodoxime levels Details Probenecid Cefprozil Cefzil® Increased serum cefprozil levels Details Probenecid Dapsone Aczone An increased risk of dapsone toxicity (hemolytic anemia, methemoglobinemia, lethargy, weakness) Details Probenecid Dapsone Topical Aczone An increased risk of dapsone toxicity (hemolytic anemia, methemoglobinemia, lethargy, weakness) Details Probenecid Entacapone Comtan An increased risk of enhanced entacapone adverse effects (diarrhea, dyskinesias) Details Probenecid Ertapenem Injection Invanz Increased plasma concentrations of ertapenem Details Probenecid Famotidine Calmicid Increased OAT3 substrate exposure Details Probenecid Famotidine Injection Calmicid Increased OAT3 substrate exposure Details Probenecid Ganciclovir Cytovene® Oral Increased risk for ganciclovir toxicity Details Probenecid Ganciclovir Injection Cytovene® I.V.® Increased risk for ganciclovir toxicity Details Probenecid Ganciclovir Ophthalmic Zirgan Increased risk for ganciclovir toxicity Details Probenecid Gatifloxacin Ophthalmic Zymar® An increase in the serum level of gatifloxacin Details Probenecid Meropenem Increased meropenem exposure Details Probenecid Meropenem Injection Merrem® Increased meropenem exposure Details Probenecid Oseltamivir Tamiflu Increased OAT3 substrate exposure Details Probenecid Pemetrexed Injection Alimta Pemetrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal toxicity) Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.