Procyclidine

12 interactions 2 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Acetaminophen And Codeine Buprenorphine Fentanyl Transdermal Patch Glucagon Injection Glucagon Injection / Solution Glucagon Nasal Powder
12 Major
All (12) Major (12)

Major

Procyclidine Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of paralytic ileus Details Procyclidine Buprenorphine Belbuca Explained An increased risk of paralytic ileus Details Procyclidine Fentanyl Transdermal Patch Duragesic® Increased risk of urinary retention and/or severe constipation, which may lead to paralytic ileus Details Procyclidine Glucagon Injection Baqsimi Increased risk of gastrointestinal side effects Details Procyclidine Glucagon Injection / Solution Baqsimi Increased risk of gastrointestinal side effects Details Procyclidine Glucagon Nasal Powder Baqsimi Increased risk of gastrointestinal side effects Details Procyclidine Glycopyrronium Topical Cuvposa® An increased risk of anticholinergic side effects Details Procyclidine Hydromorphone Injection Dilaudid Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Procyclidine Hydromorphone Rectal available generically Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Procyclidine Metoclopramide Injection Gimoti Diminished effectiveness of metoclopramide and the dopaminergic agent Details Procyclidine Metoclopramide Nasal Spray Gimoti Diminished effectiveness of metoclopramide and the dopaminergic agent Details Procyclidine Morphine Injection Astramorph® PF Increased risk of urinary retention, severe constipation, and paralytic ileus Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.