Rabeprazole

Name: Rabeprazole Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

28 interactions 1 explained in plain English

Also sold as: Aciphex AcipHex® AcipHex® Sprinkles

About Rabeprazole

Rabeprazole is a proton-pump inhibitor used to treat acid reflux, stomach ulcers, and conditions involving excess stomach acid. Read the full Rabeprazole drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Methotrexate Belumosudil Octreotide Ketoconazole Topical Gefitinib Octreotide Injection

21 Major 7 Moderate

All (28) Major (21) Moderate (7)

Moderate

Rabeprazole Ampicillin Amcill® Loss of ampicillin efficacy Details Rabeprazole Ampicillin Injection Omnipen-N® Loss of ampicillin efficacy Details Rabeprazole Clopidogrel Plavix Reduced antiplatelet activity Details Rabeprazole Cyclosporine Injection Atopica Increased cycloSPORINE exposure Details Rabeprazole Cyclosporine Ophthalmic Cequa Increased cycloSPORINE exposure Details Rabeprazole Doxycycline Injection Acticlate Reduced doxycycline efficacy Details Rabeprazole Levothyroxine Ermeza Reduced efficacy of levothyroxine and an increased risk of hypothyroidism Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.