Rabeprazole

28 interactions 1 explained in plain English
Also sold as: Aciphex AcipHex® AcipHex® Sprinkles
About Rabeprazole

Rabeprazole is a proton-pump inhibitor used to treat acid reflux, stomach ulcers, and conditions involving excess stomach acid. Read the full Rabeprazole drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Methotrexate Belumosudil Octreotide Ketoconazole Topical Gefitinib Octreotide Injection
21 Major 7 Moderate
All (28) Major (21) Moderate (7)

Major

Rabeprazole Acalabrutinib Calquence Reduced acalabrutinib exposure Details Rabeprazole Belumosudil Rezurock Explained Reduced belumosudil exposure Details Rabeprazole Atezolizumab Injection Tecentriq Impaired efficacy of atezolizumab Details Rabeprazole Bosutinib Bosulif Reduced bosutinib exposure Details Rabeprazole Capecitabine Xeloda Reduction in capecitabine efficacy Details Rabeprazole Cefuroxime Ceftin® Decreased cefuroxime axetil exposure Details Rabeprazole Dacomitinib Vizimpro Reduced dacomitinib exposure Details Rabeprazole Dasatinib Phyrago Reduced dasatinib exposure Details Rabeprazole Digoxin Cardoxin® An increased digoxin exposure Details Rabeprazole Erlotinib Tarceva Reduced erlotinib exposure Details Rabeprazole Gefitinib Iressa Decreased exposure of gefitinib Details Rabeprazole Infigratinib Truseltiq Decreased infigratinib plasma concentrations Details Rabeprazole Ketoconazole Topical Extina® Foam Reduced ketoconazole exposure and reduced efficacy of ketoconazole Details Rabeprazole Methotrexate Jylamvo Increased risk of methotrexate toxicity Details Rabeprazole Methotrexate Injection Abitrexate® Increased risk of methotrexate toxicity Details Rabeprazole Methylphenidate Adhansia XR® Altered pharmacodynamic and changes in release profile of methylphenidate Details Rabeprazole Methylphenidate Transdermal Patch Daytrana Altered pharmacodynamic and changes in release profile of methylphenidate Details Rabeprazole Neratinib Nerlynx Decreased neratinib solubility, absorption, and exposure Details Rabeprazole Nivolumab Injection Opdivo Reduced efficacy of nivolumab Details Rabeprazole Octreotide Bynfezia Decreased octreotide bioavailability Details Rabeprazole Octreotide Injection Bynfezia Decreased octreotide bioavailability Details

Moderate

Rabeprazole Ampicillin Amcill® Loss of ampicillin efficacy Details Rabeprazole Ampicillin Injection Omnipen-N® Loss of ampicillin efficacy Details Rabeprazole Clopidogrel Plavix Reduced antiplatelet activity Details Rabeprazole Cyclosporine Injection Atopica Increased cycloSPORINE exposure Details Rabeprazole Cyclosporine Ophthalmic Cequa Increased cycloSPORINE exposure Details Rabeprazole Doxycycline Injection Acticlate Reduced doxycycline efficacy Details Rabeprazole Levothyroxine Ermeza Reduced efficacy of levothyroxine and an increased risk of hypothyroidism Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.