Reboxetine and Linezolid Injection: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Linezolid Injection
Reboxetine
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Hyperthermia, rigidity, myoclonus, seizures, fluctuations of vital signs, or mental status changes
Interaction Deep Dive
Drug interactions between reboxetine and monoamine oxidase inhibitors (MAOI) have not been studied. Concurrent administration or overlapping therapy with reboxetine and an MAOI may result in CNS toxicity or serotonin syndrome, a hyperserotonergic state characterized by symptoms such as restlessness, myoclonus, changes in mental status, hyperreflexia, diaphoresis, shivering, and tremor. Serious, even fatal, reactions have been reported with concomitant use of serotonin specific reuptake inhibitors and MAO inhibitors12. Although reboxetine possesses weak serotonergic properties and there are no human data pertinent to such an interaction, reboxetine should not be used in combination with an MAOI or within 7 days of initiating or 14 days of discontinuing therapy with an MAOI 3.
Why it happens (mechanism)
Serotonin reuptake inhibition
Common questions
Can I take Reboxetine and Linezolid Injection together?
Hyperthermia, rigidity, myoclonus, seizures, fluctuations of vital signs, or mental status changes Always confirm with your pharmacist or prescriber before making any change.
How serious is the Reboxetine and Linezolid Injection interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "rapid". Effects can appear quickly, often within about 24 hours of combining the drugs.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Reboxetine or Linezolid Injection need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (3)
- Lappin RI & Auchincloss EL: Treatment of the serotonin syndrome with cyproheptadine. N Engl J Med 1994; 331:1021-1022. PubMed
- Graber MA, Hoehns TB, & Perry PJ: Sertraline-phenelzine drug interaction: a serotonin syndrome reaction. Ann Pharmacother 1994; 28:732-735. DOI
- Product Information: Edronax(R), reboxetine. Pharmacia & Upjohn Company, Kalamazoo, MI, 1999.
Keep reading about Linezolid Injection
Keep reading about Reboxetine
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