Relugolix and Dengue Tetravalent Vaccine, Live: Interaction Details
AI-assisted, pharmacist-reviewed · AI content regenerated Jul 11, 2026 · Source data updated Jul 2, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Relugolix
Dengue Tetravalent Vaccine, Live
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
These two don't mix well together. The dengue vaccine is a live vaccine, which means it uses a weakened form of the virus to teach your body how to fight it. If your immune system is weakened, that weakened virus can sometimes actually cause an infection instead of just training your defenses.
Relugolix (Orgovyx) is used to treat certain cancers, and both the underlying illness and the treatment can lower how well your immune system responds. Because of that, a live vaccine like this one is generally not given. The good news is your care team can plan around this and choose safe options, so talk with your doctor or pharmacist before getting any vaccine.
Interaction: Live attenuated dengue tetravalent vaccine is contraindicated in patients who are immunosuppressed due to disease or therapy.
- Direction/effect: Reduced immune response permits uncontrolled replication of the attenuated virus, raising the risk of vaccine-derived infection.
- Mechanism: Immunosuppression associated with the malignancy and/or antineoplastic therapy (relugolix). Not a pharmacokinetic interaction; neither agent is a prodrug.
- Evidence: Established. Onset: unspecified.
- Management: Avoid the live dengue vaccine during immunosuppression. Patients with malignancy in remission, restored immunocompetence, and chemotherapy discontinued for at least 3 months may be candidates. Consider non-live alternatives or defer per specialist guidance.
What happens
An increased risk of infection by the live vaccine
Interaction Deep Dive
The dengue virus vaccine should not be given to people who have severe immunodeficiency or immunosuppression stemming from illness or treatment 2. A live vaccine may be given to patients with leukemia, lymphoma, or other malignancies provided their disease is in remission, their immunocompetence has been restored, and at least 3 months have elapsed since chemotherapy was stopped 1.
Why it happens (mechanism)
Decreased immune response allows live vaccine to produce infection
How to manage this interaction
What your care team typically does:
- Avoid giving the live dengue vaccine while you are being treated with relugolix or are otherwise immunosuppressed.
- Assess your immune status. People whose cancer is in remission, whose immune system has recovered, and who have been off chemotherapy for at least 3 months may be able to receive a live vaccine.
- Consider timing the vaccine for a period of restored immunocompetence, or choosing an alternative.
What you should do: Keep taking relugolix exactly as prescribed. Do not get any vaccine, especially a live one, without first checking with your prescriber or pharmacist so they can confirm it is safe and time it correctly.
Management is individual — confirm any change with your pharmacist or prescriber.
Common questions
Can I take Relugolix and Dengue Tetravalent Vaccine, Live together?
Do not receive the live dengue vaccine while taking relugolix or while immunosuppressed, because the weakened vaccine virus could cause an actual infection. Talk with your care team, who can time vaccination for a period of restored immune function or choose a safe alternative. Always confirm with your pharmacist or prescriber before making any change.
How serious is the Relugolix and Dengue Tetravalent Vaccine, Live interaction?
It is rated contraindicated. These should generally not be used together.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How is the Relugolix and Dengue Tetravalent Vaccine, Live interaction managed?
What your care team typically does: Avoid giving the live dengue vaccine while you are being treated with relugolix or are otherwise immunosuppressed. Assess your immune status. People whose cancer is in remission, whose immune system has recovered, and who have been off chemotherapy for at least 3 months may be able to receive a live vaccine. Consider timing the vaccine for a period of restored i… Management is individual — always follow your own care team's guidance.
How strong is the evidence for this interaction?
The evidence is graded "established". Well documented — supported by controlled studies or strong clinical data.
Questions for your pharmacist
- Does my dose of Relugolix or Dengue Tetravalent Vaccine, Live need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (2)
- Centers for Disease Control and Prevention (CDC): Vaccines & Immunizations: altered immunocompetence. Centers for Disease Control and Prevention (CDC). Atlanta, GA. 2024.
- Product Information: DENGVAXIA(R) subcutaneous injection suspension, dengue tetravalent vaccine, live subcutaneous injection suspension. Sanofi Pasteur Inc (per manufacturer), Swiftwater, PA, 2019. DailyMed
Keep reading about Relugolix
Keep reading about Dengue Tetravalent Vaccine, Live
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