Relugolix

340 interactions 260 explained in plain English 125 cited references

Also sold as: Orgovyx Orgovyx®

About Relugolix

Relugolix is a gonadotropin-releasing hormone receptor antagonist used to treat advanced prostate cancer in adult men. Read the full Relugolix drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 2, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Dronedarone Dengue Tetravalent Vaccine, Live Levoketoconazole Measles Virus Vaccine, Live Mesoridazine Mumps Virus Vaccine, Live

22 Contraindicated 313 Major 5 Moderate

All (340) Contraindicated (22) Major (313) Moderate (5)

Contraindicated

Relugolix Bacillus Of Calmette And Guerin Vaccine, Live Explained An increased risk of infection by the live vaccine Details Relugolix Bepridil Explained An increased risk of QT interval prolongation Details Relugolix Cisapride Propulsid® Explained Increased risk of QT interval prolongation Details Relugolix Dengue Tetravalent Vaccine, Live Explained An increased risk of infection by the live vaccine Details Relugolix Dronedarone Multaq Explained Increased relugolix exposure and an increased risk of QT interval prolongation Details Relugolix Levoketoconazole Recorlev Explained An increased risk of QT interval prolongation and an increased risk of torsade de pointes Details Relugolix Measles Virus Vaccine, Live Explained An increased risk of infection by the live vaccine Details Relugolix Mesoridazine Explained An increased risk of QT interval prolongation Details Relugolix Mumps Virus Vaccine, Live Explained An increased risk of infection by the live vaccine Details Relugolix Pimozide Explained An increased risk of QT interval prolongation Details Relugolix Piperaquine Explained An increased risk of QT interval prolongation Details Relugolix Ranolazine Aspruzyo Explained Reduced ranolazine exposure, increased relugolix exposure and an increased risk of QT interval prolongation Details Relugolix Rubella Virus Vaccine, Live Explained An increased risk of infection by the live vaccine Details Relugolix Saquinavir Explained An increased risk of QT interval prolongation Details Relugolix Smallpox Monkeypox Vaccine Explained An increased risk of infection by the live vaccine Details Relugolix Sparfloxacin Explained An increased risk of QT interval prolongation Details Relugolix Terfenadine Explained An increased risk of QT interval prolongation Details Relugolix Thioridazine Explained An increased risk of QT interval prolongation Details Relugolix Typhoid Vaccine Typhim VI® Explained An increased risk of infection by the live vaccine Details Relugolix Varicella Virus Vaccine, Live Explained An increased risk of infection by the live vaccine Details Relugolix Yellow Fever Vaccine Stamaril Explained An increased risk of infection by the live vaccine Details Relugolix Ziprasidone Geodon Explained An increased risk of QT interval prolongation Details

Major

Relugolix Amitriptyline Elavil Explained Increased risk of QT interval prolongation Details Relugolix Sertraline Explained Increased risk of QT interval prolongation Details Relugolix Buprenorphine Belbuca Explained Increased risk of QT interval prolongation Details Relugolix Abrocitinib Cibinqo Explained Increased relugolix exposure Details Relugolix Adagrasib Krazati Explained Increased relugolix exposure and an increased risk of QT interval prolongation Details Relugolix Adenovirus Vaccine Type 4, Live Explained An increased risk of infection by the live vaccine Details Relugolix Adenovirus Vaccine Type 7, Live Explained An increased risk of infection by the live vaccine Details Relugolix Alfentanil Explained Reduced ALfentanil exposure, reduced efficacy of ALfentanil and an increased risk of a withdrawal syndrome Details Relugolix Alfuzosin UroXatral Increased risk of QT interval prolongation Details Relugolix Alogliptin Nesina Increased relugolix exposure Details Relugolix Amiodarone Nexterone Explained Increased relugolix exposure and an increased risk of QT interval prolongation Details Relugolix Amisulpride Barhemsys Explained Increased risk of QT interval prolongation Details Relugolix Amlodipine Amvaz® Reduced amLODIPine exposure Details Relugolix Anagrelide Agrylin Increased risk of QT interval prolongation Details Relugolix Apalutamide Erleada Explained Reduced relugolix exposure and reduced efficacy of relugolix Details Relugolix Apomorphine Apokyn Explained Increased risk of QT interval prolongation Details Relugolix Aripiprazole Abilify Explained Increased risk of QT interval prolongation Details Relugolix Aripiprazole Lauroxil Aristada Explained Increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.