Relugolix and Rubella Virus Vaccine, Live: Interaction Details
AI-assisted, pharmacist-reviewed · AI content regenerated Jul 11, 2026 · Source data updated Jul 2, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Relugolix
Rubella Virus Vaccine, Live
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
Relugolix (Orgovyx) is used to treat cancers like advanced prostate cancer. When your body is fighting cancer or getting cancer-related treatment, your immune system may not be at full strength. A live vaccine like the rubella vaccine contains a weakened but living virus. In a healthy person, the immune system easily controls it. But if your defenses are lowered, that weakened virus could actually spread and cause an infection instead of just building protection.
Because of this, live rubella vaccine is generally not given in this situation. The good news is your care team can plan safe vaccine timing for you, so always let them know before getting any vaccine.
Interaction: Live rubella vaccine is contraindicated in patients who are immunocompromised, including those with malignancy or receiving cancer-directed/immunosuppressive therapy (context in which relugolix is used).
- Mechanism: Attenuated live virus plus impaired humoral/cellular immunity, allowing uncontrolled viral replication and disseminated vaccine-strain infection.
- Direction: Reduced immune competence, increased infection risk from the vaccine (neither agent is metabolically activated; this is a PD/immune interaction, not PK).
- Evidence: Established; per CDC guidance.
- Management: Do not administer during active immunosuppression. Live vaccines may be considered once immunocompetence is restored and chemotherapy has been discontinued at least 3 months, per CDC.
What happens
An increased risk of infection by the live vaccine
Interaction Deep Dive
Because of the potential for disseminated infection with the vaccine virus, rubella virus vaccine should not be given to people who have severe humoral or cellular immunodeficiency, whether primary or acquired 3. The CDC advises that rubella vaccine is contraindicated for patients who have hematologic and solid tumors, those undergoing chemotherapy, those with congenital immunodeficiency, and those on long-term immunosuppressive therapy 2. A live vaccine may be administered to patients with leukemia, lymphoma, or other malignancies provided their disease is in remission, their immunocompetence has been restored, and chemotherapy has been stopped for a minimum of 3 months 1.
Why it happens (mechanism)
Decreased immune response allows live vaccine to produce infection
How to manage this interaction
What your care team typically does:
- Avoids giving the live rubella vaccine while you are immunocompromised or under active cancer treatment.
- Reviews your immune status and treatment timeline to decide when live vaccines are safe. Per CDC guidance, live vaccines may be given once immune function is restored and chemotherapy has been stopped for at least 3 months.
- May recommend non-live vaccine options or vaccinating close contacts to protect you.
What you should do:
- Keep taking your prescribed relugolix as directed.
- Tell your pharmacist or prescriber before getting any vaccine, and confirm timing with them.
Management is individual — confirm any change with your pharmacist or prescriber.
Common questions
Can I take Relugolix and Rubella Virus Vaccine, Live together?
Do not receive the live rubella vaccine while immunocompromised or on active cancer treatment; check with your care team about safe timing for any vaccine. Always confirm with your pharmacist or prescriber before making any change.
How serious is the Relugolix and Rubella Virus Vaccine, Live interaction?
It is rated contraindicated. These should generally not be used together.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How is the Relugolix and Rubella Virus Vaccine, Live interaction managed?
What your care team typically does: Avoids giving the live rubella vaccine while you are immunocompromised or under active cancer treatment. Reviews your immune status and treatment timeline to decide when live vaccines are safe. Per CDC guidance, live vaccines may be given once immune function is restored and chemotherapy has been stopped for at least 3 months. May recommend non-live vaccine opti… Management is individual — always follow your own care team's guidance.
How strong is the evidence for this interaction?
The evidence is graded "established". Well documented — supported by controlled studies or strong clinical data.
Questions for your pharmacist
- Does my dose of Relugolix or Rubella Virus Vaccine, Live need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (3)
- Centers for Disease Control and Prevention (CDC): Vaccines & Immunizations: altered immunocompetence. Centers for Disease Control and Prevention (CDC). Atlanta, GA. 2024.
- National Center for Immunization and Respiratory Diseases (NCIRD): Vaccines & immunizations: contraindications and precautions. Centers for Disease Control and Prevention (CDC). Atlanta, GA. 2024.
- Product Information: PRIORIX subcutaneous suspension, measles, mumps, rubella vaccine, live subcutaneous suspension. GlaxoSmithKline (per manufacturer), Research Triangle Park, NC, 2022. DailyMed
Keep reading about Relugolix
Keep reading about Rubella Virus Vaccine, Live
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