Relugolix and Ebola Zaire Vaccine, Live: Interaction Details
AI-assisted, pharmacist-reviewed · AI content regenerated Jul 11, 2026 · Source data updated Jul 2, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Relugolix
Ebola Zaire Vaccine, Live
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
Here's what's going on. Relugolix (Orgovyx) is used to treat certain cancers, and being on cancer treatment can lower how well your immune system works. The Ebola Zaire vaccine is a live vaccine, meaning it contains a weakened but living form of the virus. In someone with a weakened immune system, the body may not control even that weakened virus well, so the vaccine itself could cause an infection instead of just protecting you.
The good news is this is very manageable. Please don't stop either one on your own. Just talk with your doctor or pharmacist before getting any live vaccine so they can decide the safest timing for you.
Mechanism: Relugolix is a GnRH antagonist used in cancer therapy; the associated immunosuppression can blunt immune defenses. A live attenuated vaccine (Ebola Zaire) may then replicate unchecked, risking vaccine-derived infection. Neither agent is a prodrug and this is a pharmacodynamic, not metabolic, interaction.
- Direction: reduced immune response, increased risk of live-vaccine infection and possibly diminished vaccine efficacy
- Evidence: established; onset unspecified
- Severity: major
Management: Severely immunocompromised patients generally should not receive live vaccines. Safety/efficacy in immunocompromised individuals is not established. Assess immunocompetence; defer live vaccination and individualize timing per specialist guidance.
What happens
An increased risk of infection by the live vaccine
Interaction Deep Dive
As a rule, live vaccines should not be administered to patients who are severely immunocompromised2. In immunocompromised individuals, the ebola vaccine has not been assessed for either safety or efficacy, and its effectiveness in such patients could be reduced3. A live vaccine may be given to patients with leukemia, lymphoma, or other malignancies provided their disease is in remission, their immunocompetence has returned, and chemotherapy has been stopped for a minimum of 3 months1.
Why it happens (mechanism)
Decreased immune response allows live vaccine to produce infection
How to manage this interaction
What your care team may do:
- Review how immunosuppressed you are before giving any live vaccine, including the Ebola Zaire vaccine.
- Generally avoid live vaccines while your immune system is significantly suppressed.
- Consider timing: patients whose disease is in remission and who have regained normal immune function, with chemotherapy stopped for at least 3 months, may be able to receive a live vaccine.
What you should do: Keep taking relugolix as prescribed. Do not get any live vaccine without first checking with your oncologist or pharmacist so they can time it safely for you.
Management is individual — confirm any change with your pharmacist or prescriber.
Common questions
Can I take Relugolix and Ebola Zaire Vaccine, Live together?
Because relugolix-based cancer treatment can weaken your immune system, a live vaccine like Ebola Zaire could cause infection and may work less well. Do not get any live vaccine without clearing the timing with your care team first. Always confirm with your pharmacist or prescriber before making any change.
How serious is the Relugolix and Ebola Zaire Vaccine, Live interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How is the Relugolix and Ebola Zaire Vaccine, Live interaction managed?
What your care team may do: Review how immunosuppressed you are before giving any live vaccine, including the Ebola Zaire vaccine. Generally avoid live vaccines while your immune system is significantly suppressed. Consider timing: patients whose disease is in remission and who have regained normal immune function, with chemotherapy stopped for at least 3 months, may be able to receive a live vacc… Management is individual — always follow your own care team's guidance.
How strong is the evidence for this interaction?
The evidence is graded "established". Well documented — supported by controlled studies or strong clinical data.
Questions for your pharmacist
- Does my dose of Relugolix or Ebola Zaire Vaccine, Live need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (3)
- Centers for Disease Control and Prevention (CDC): Vaccines & Immunizations: altered immunocompetence. Centers for Disease Control and Prevention (CDC). Atlanta, GA. 2024.
- National Center for Immunization and Respiratory Diseases (NCIRD): Vaccines & immunizations: contraindications and precautions. Centers for Disease Control and Prevention (CDC). Atlanta, GA. 2024.
- Product Information: Adenovirus type 4 and type 7 vaccine live oral enteric- coated tablets, adenovirus type 4 and type 7 vaccine live oral enteric coated tablets. Teva Pharmaceuticals USA Inc (per FDA), North Wales, PA, 2019. DailyMed
Keep reading about Relugolix
Keep reading about Ebola Zaire Vaccine, Live
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