Relugolix

340 interactions 260 explained in plain English 125 cited references

Also sold as: Orgovyx Orgovyx®

About Relugolix

Relugolix is a gonadotropin-releasing hormone receptor antagonist used to treat advanced prostate cancer in adult men. Read the full Relugolix drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 2, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Dronedarone Dengue Tetravalent Vaccine, Live Levoketoconazole Measles Virus Vaccine, Live Mesoridazine Mumps Virus Vaccine, Live

22 Contraindicated 313 Major 5 Moderate

All (340) Contraindicated (22) Major (313) Moderate (5)

Major

Relugolix Fluoxetine RECONCILE Explained Increased risk of QT interval prolongation Details Relugolix Fluvoxamine Explained Increased relugolix exposure Details Relugolix Formoterol Perforomist Explained Increased risk of QT interval prolongation Details Relugolix Foscarnet Foscavir Explained Increased risk of QT interval prolongation Details Relugolix Fosphenytoin Cerebyx Explained Reduced relugolix exposure, reduced efficacy of relugolix and an increased risk of QT interval prolongation Details Relugolix Fostamatinib Tavalisse Increased relugolix exposure Details Relugolix Galantamine Razadyne Increased risk of QT interval prolongation Details Relugolix Gatifloxacin Zymaxid Explained Increased risk of QT interval prolongation Details Relugolix Gemifloxacin Factive Increased risk of QT interval prolongation Details Relugolix Ginkgo Explained Increased relugolix exposure Details Relugolix Ginseng Explained Increased relugolix exposure Details Relugolix Givinostat Duvyzat Explained Increased risk of QT interval prolongation Details Relugolix Glasdegib Daurismo Increased risk of QT interval prolongation Details Relugolix Glecaprevir Explained Increased relugolix exposure Details Relugolix Gonadorelin Explained Increased risk of QT interval prolongation Details Relugolix Goserelin Explained Increased risk of QT interval prolongation Details Relugolix Granisetron Explained Increased risk of QT interval prolongation Details Relugolix Halofantrine Explained Increased risk of QT interval prolongation Details Relugolix Haloperidol Explained Increased risk of QT interval prolongation Details Relugolix Histrelin Supprelin Explained Increased risk of QT interval prolongation Details Relugolix Hydroquinidine Explained Increased risk of QT interval prolongation Details Relugolix Hydroxychloroquine Plaquenil Increased risk of QT interval prolongation Details Relugolix Hydroxyzine Explained Increased risk of QT interval prolongation Details Relugolix Ibrexafungerp Brexafemme Increased relugolix exposure Details Relugolix Ibrutinib Imbruvica Increased relugolix exposure Details Relugolix Ibutilide Corvert Explained Increased risk of QT interval prolongation Details Relugolix Iloperidone Fanapt Explained Increased risk of QT interval prolongation Details Relugolix Imipramine Explained Increased risk of QT interval prolongation Details Relugolix Indinavir Explained Increased relugolix exposure Details Relugolix Influenza Virus Vaccine, Live Explained An increased risk of infection by the live vaccine Details Relugolix Inotuzumab Ozogamicin Besponsa Explained Increased risk of QT interval prolongation Details Relugolix Isavuconazole Explained Increased relugolix exposure Details Relugolix Isavuconazonium Cresemba Explained Increased relugolix exposure Details Relugolix Isavuconazonium Sulfate Cresemba Explained Increased relugolix exposure Details Relugolix Isoflurane Fluriso Explained Increased risk of QT interval prolongation Details Relugolix Istradefylline Nourianz Increased relugolix exposure Details Relugolix Itraconazole Sporanox Explained Increased relugolix exposure and an increased risk of QT interval prolongation Details Relugolix Ivabradine Corlanor Increased risk of QT interval prolongation Details Relugolix Ivacaftor Kalydeco Explained Increased relugolix exposure Details Relugolix Ivosidenib Tibsovo Explained Increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.