Relugolix

340 interactions 260 explained in plain English 125 cited references

Also sold as: Orgovyx Orgovyx®

About Relugolix

Relugolix is a gonadotropin-releasing hormone receptor antagonist used to treat advanced prostate cancer in adult men. Read the full Relugolix drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 2, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Dronedarone Dengue Tetravalent Vaccine, Live Levoketoconazole Measles Virus Vaccine, Live Mesoridazine Mumps Virus Vaccine, Live

22 Contraindicated 313 Major 5 Moderate

All (340) Contraindicated (22) Major (313) Moderate (5)

Major

Relugolix Ketoconazole Extina Explained Increased relugolix exposure and an increased risk of QT interval prolongation Details Relugolix Lapatinib Tykerb Explained Increased relugolix exposure and an increased risk of QT interval prolongation Details Relugolix Lasmiditan Reyvow Explained Increased relugolix exposure Details Relugolix Lefamulin Xenleta Increased risk of QT interval prolongation Details Relugolix Lenacapavir Sunlenca Explained Increased relugolix exposure Details Relugolix Lenvatinib Lenvima Increased risk of QT interval prolongation Details Relugolix Leuprolide Eligard Explained Increased risk of QT interval prolongation Details Relugolix Levofloxacin Levaquin Increased risk of QT interval prolongation Details Relugolix Lofexidine Explained Increased risk of QT interval prolongation Details Relugolix Lonafarnib Zokinvy Explained Increased relugolix exposure Details Relugolix Loperamide Diamode Increased risk of QT interval prolongation Details Relugolix Lumateperone Caplyta Reduced lumateperone exposure Details Relugolix Lumefantrine Explained Reduced artemether/lumefantrine exposure, reduced efficacy of artemether/lumefantrine, loss of antimalarial efficacy and an increa... Details Relugolix Macimorelin Explained Increased risk of QT interval prolongation Details Relugolix Maribavir Livtencity Explained Increased relugolix exposure Details Relugolix Mavorixafor Xolremdi Explained Increased relugolix exposure and an increased risk of QT interval prolongation Details Relugolix Mefloquine Lariam® Increased risk of QT interval prolongation Details Relugolix Methadone Diskets Explained Increased risk of QT interval prolongation Details Relugolix Methotrimeprazine Explained Increased risk of QT interval prolongation Details Relugolix Metronidazole Flagyl Increased risk of QT interval prolongation Details Relugolix Mibefradil Explained Increased relugolix exposure Details Relugolix Midostaurin Rydapt Increased relugolix exposure Details Relugolix Mifepristone Korlym Explained Increased relugolix exposure and an increased risk of QT interval prolongation Details Relugolix Milk Thistle Explained Increased relugolix exposure Details Relugolix Mirabegron Myrbetriq Explained Increased relugolix exposure Details Relugolix Mirtazapine Mirataz Explained Increased risk of QT interval prolongation Details Relugolix Mizolastine Explained Increased risk of QT interval prolongation Details Relugolix Mobocertinib Exkivity Explained Increased risk of QT interval prolongation Details Relugolix Moricizine Explained Increased risk of QT interval prolongation Details Relugolix Moxifloxacin Avelox Increased risk of QT interval prolongation Details Relugolix Nafarelin Explained Increased risk of QT interval prolongation Details Relugolix Nefazodone Explained Increased relugolix exposure Details Relugolix Nelfinavir Viracept Explained Increased relugolix exposure and an increased risk of QT interval prolongation Details Relugolix Neratinib Nerlynx Increased relugolix exposure Details Relugolix Nifedipine Adalat® Increased relugolix exposure and reduced NIFEdipine exposure Details Relugolix Nilotinib Explained Increased risk of QT interval prolongation Details Relugolix Nirmatrelvir Explained Increased relugolix exposure Details Relugolix Norfloxacin Explained Increased risk of QT interval prolongation Details Relugolix Octreotide Bynfezia Increased risk of QT interval prolongation Details Relugolix Ofloxacin Floxin® Increased risk of QT interval prolongation Details

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