Relugolix

340 interactions 260 explained in plain English 125 cited references

Also sold as: Orgovyx Orgovyx®

About Relugolix

Relugolix is a gonadotropin-releasing hormone receptor antagonist used to treat advanced prostate cancer in adult men. Read the full Relugolix drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 2, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

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22 Contraindicated 313 Major 5 Moderate

All (340) Contraindicated (22) Major (313) Moderate (5)

Major

Relugolix Sarecycline Seysara Explained Increased relugolix exposure Details Relugolix Schizandra Explained Increased relugolix exposure Details Relugolix Selpercatinib Retevmo Explained Increased risk of QT interval prolongation Details Relugolix Sertindole Explained Increased risk of QT interval prolongation Details Relugolix Sevoflurane Petrem Explained Increased risk of QT interval prolongation Details Relugolix Simeprevir Olysio® Explained Increased relugolix exposure Details Relugolix Siponimod Mayzent Explained Increased risk of QT interval prolongation Details Relugolix Sodium Phosphate OsmoPrep Explained Increased risk of QT interval prolongation Details Relugolix Sodium Phosphate, Dibasic Explained Increased risk of QT interval prolongation Details Relugolix Sodium Phosphate, Monobasic Explained Increased risk of QT interval prolongation Details Relugolix Sofosbuvir Sovaldi Explained Increased relugolix exposure Details Relugolix Solifenacin Vesicare Explained Increased risk of QT interval prolongation Details Relugolix Sorafenib Nexavar Explained Increased risk of QT interval prolongation Details Relugolix Sotagliflozin Inpefa Explained Increased relugolix exposure Details Relugolix Sotalol Betapace Explained Increased risk of QT interval prolongation Details Relugolix Sotorasib Lumakras Explained Increased relugolix exposure Details Relugolix Spironolactone Aldactone Explained Increased relugolix exposure Details Relugolix St John's Wort Explained Altered relugolix exposure, an increased risk of relugolix-related adverse reactions and reduced efficacy of relugolix Details Relugolix Sulpiride Explained Increased risk of QT interval prolongation Details Relugolix Sultopride Explained Increased risk of QT interval prolongation Details Relugolix Sunitinib Sutent Explained Increased risk of QT interval prolongation Details Relugolix Suvorexant Belsomra Explained Increased relugolix exposure Details Relugolix Tacrolimus Astagraf Explained Increased risk of QT interval prolongation Details Relugolix Taletrectinib Ibtrozi Explained Increased risk of QT interval prolongation Details Relugolix Tamoxifen Nolvadex® Explained Increased risk of QT interval prolongation Details Relugolix Telaprevir Explained Increased relugolix exposure and an increased risk of QT interval prolongation Details Relugolix Telavancin Vibativ Explained Increased risk of QT interval prolongation Details Relugolix Telithromycin Explained Increased relugolix exposure and an increased risk of QT interval prolongation Details Relugolix Telmisartan Micardis Explained Increased relugolix exposure Details Relugolix Tepotinib Tepmetko Explained Increased relugolix exposure Details Relugolix Tetrabenazine Xenazine Explained Increased risk of QT interval prolongation Details Relugolix Tezacaftor Explained Increased relugolix exposure Details Relugolix Ticagrelor Brilinta Explained Increased relugolix exposure Details Relugolix Tolterodine Detrol Explained Increased risk of QT interval prolongation Details Relugolix Tolvaptan Jynarque Explained Increased relugolix exposure Details Relugolix Toremifene Fareston Explained Increased risk of QT interval prolongation Details Relugolix Tramadol ConZip Explained Reduced traMADol exposure and reduced efficacy of traMADol Details Relugolix Trazodone Raldesy Explained Increased risk of QT interval prolongation Details Relugolix Triclabendazole Egaten Explained Increased risk of QT interval prolongation Details Relugolix Trimipramine Explained Increased risk of QT interval prolongation Details

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