Relugolix

340 interactions 260 explained in plain English 125 cited references
Also sold as: Orgovyx Orgovyx®
About Relugolix

Relugolix is a gonadotropin-releasing hormone receptor antagonist used to treat advanced prostate cancer in adult men. Read the full Relugolix drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 2, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

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22 Contraindicated 313 Major 5 Moderate
All (340) Contraindicated (22) Major (313) Moderate (5)

Major

Relugolix Inotuzumab Ozogamicin Injection Besponsa Increased risk of QT interval prolongation Details Relugolix Ketoconazole Topical Extina® Foam Increased relugolix exposure and an increased risk of QT interval prolongation Details Relugolix Lenacapavir Injection Sunlenca Increased relugolix exposure Details Relugolix Lenacapavir Oral Sunlenca Increased relugolix exposure Details Relugolix Levofloxacin Injection Levaquin Increased risk of QT interval prolongation Details Relugolix Metronidazole Injection Flagyl Increased risk of QT interval prolongation Details Relugolix Metronidazole Topical MetroCream® Increased risk of QT interval prolongation Details Relugolix Metronidazole Vaginal MetroGel® Vaginal Increased risk of QT interval prolongation Details Relugolix Moxifloxacin Injection Avelox Increased risk of QT interval prolongation Details Relugolix Moxifloxacin Ophthalmic Moxeza® Increased risk of QT interval prolongation Details Relugolix Nafarelin Nasal Spray Synarel Increased risk of QT interval prolongation Details Relugolix Octreotide Injection Bynfezia Increased risk of QT interval prolongation Details Relugolix Ofloxacin Ophthalmic Ocuflox Increased risk of QT interval prolongation Details Relugolix Ofloxacin Otic Floxin® Otic Increased risk of QT interval prolongation Details Relugolix Oxaliplatin Injection Eloxatin® Increased risk of QT interval prolongation Details

Moderate

Relugolix Hydrocortisone Ala-Cort Reduced hydrocortisone exposure Details Relugolix Levacetylleucine Aqneursa Explained Increased P-gp inhibitor exposure and an increased risk of P-gp substrate-related adverse reactions Details Relugolix Lomitapide Explained Increased P-gp substrate exposure Details Relugolix Sparsentan Filspari Explained Increased P-gp substrate exposure and an increased risk of P-gp substrate-related adverse effects Details Relugolix Hydrocortisone Injection A-Hydrocort® Reduced hydrocortisone exposure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.