Repaglinide

65 interactions 3 explained in plain English

Also sold as: Prandin®

About Repaglinide

Repaglinide is used to treat type 2 diabetes (condition in which the body does not use insulin normally and, therefore, cannot control the amount of sugar in the blood). Repaglinide helps your body regulate the amount of glucose (sugar) in your blood. It decreases the amount of glucose by stimulating the pancreas to re… Read the full Repaglinide drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Gemfibrozil Ofloxacin Otic Octreotide Leflunomide Moxifloxacin Insulin Glulisine (Rdna Origin) Injection

1 Contraindicated 29 Major 35 Moderate

All (65) Contraindicated (1) Major (29) Moderate (35)

Major

Repaglinide Abametapir Explained Increased exposure of CYP3A4 substrate Details Repaglinide Chloroquine Aralen® Hypoglycemia Details Repaglinide Clopidogrel Plavix Increased repaglinide exposure Details Repaglinide Darolutamide Nubeqa Increased exposure of OATP1B1 or OATP1B3 substrates Details Repaglinide Delafloxacin Baxdela Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Repaglinide Delafloxacin Injection Baxdela Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Repaglinide Furosemide Injection Disal An increased risk of hyperglycemia and an increased insulin requirement Details Repaglinide Gatifloxacin Ophthalmic Zymar® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Repaglinide Gemifloxacin Factive Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Repaglinide Hydroxychloroquine Plaquenil Enhanced hypoglycemic effect of antidiabetics and an increased risk of hypoglycemia Details Repaglinide Insulin Degludec (Rdna Origin) Injection Ryzodeg® (as a combination product containing Insulin Degludec and Insulin Aspart) An increased risk of hypoglycemia Details Repaglinide Insulin Detemir (Rdna Origin) Injection Levemir An increased risk of hypoglycemia Details Repaglinide Insulin Glulisine (Rdna Origin) Injection Apidra An increased risk of hypoglycemia Details Repaglinide Ketoconazole Topical Extina® Foam Increased repaglinide exposure Details Repaglinide Lanreotide Injection Somatuline An increased risk of hypoglycemia and impaired glucose regulation Details Repaglinide Leflunomide Arava Increased repaglinide exposure Details Repaglinide Leniolisib Joenja Increased OATP1B1/OATP1B3 substrate exposure Details Repaglinide Letermovir Injection Prevymis Increased repaglinide exposure Details Repaglinide Levofloxacin Levaquin Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Repaglinide Levofloxacin Injection Levaquin Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Repaglinide Midostaurin Rydapt Increased OATP1B1 substrate exposure Details Repaglinide Moxifloxacin Avelox Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Repaglinide Moxifloxacin Injection Avelox Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Repaglinide Moxifloxacin Ophthalmic Moxeza® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Repaglinide Octreotide Bynfezia An increased risk of hypoglycemia and impaired glucose regulation Details Repaglinide Octreotide Injection Bynfezia An increased risk of hypoglycemia and impaired glucose regulation Details Repaglinide Ofloxacin Floxin® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Repaglinide Ofloxacin Ophthalmic Ocuflox Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Repaglinide Ofloxacin Otic Floxin® Otic Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.