Repaglinide

65 interactions 3 explained in plain English

Also sold as: Prandin®

About Repaglinide

Repaglinide is used to treat type 2 diabetes (condition in which the body does not use insulin normally and, therefore, cannot control the amount of sugar in the blood). Repaglinide helps your body regulate the amount of glucose (sugar) in your blood. It decreases the amount of glucose by stimulating the pancreas to re… Read the full Repaglinide drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Gemfibrozil Ofloxacin Otic Octreotide Leflunomide Moxifloxacin Insulin Glulisine (Rdna Origin) Injection

1 Contraindicated 29 Major 35 Moderate

All (65) Contraindicated (1) Major (29) Moderate (35)

Moderate

Repaglinide Lisinopril Prinivil Explained An increased risk of hypoglycemia Details Repaglinide Aspirin Acuprin® Increased risk of hypoglycemia Details Repaglinide Aspirin Rectal Aspirin Increased risk of hypoglycemia Details Repaglinide Atenolol Tenormin Explained Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Repaglinide Acebutolol Sectral® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Repaglinide Benazepril Lotensin An increased risk of hypoglycemia Details Repaglinide Abiraterone Abirtega Increased repaglinide plasma concentrations Details Repaglinide Alogliptin Nesina An increased risk of hypoglycemia Details Repaglinide Betaxolol Betoptic S Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Repaglinide Betaxolol Ophthalmic Betoptic® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Repaglinide Bisoprolol Zebeta® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Repaglinide Captopril Capoten® An increased risk of hypoglycemia Details Repaglinide Cyclosporine Injection Atopica Increased repaglinide plasma concentrations Details Repaglinide Cyclosporine Ophthalmic Cequa Increased repaglinide plasma concentrations Details Repaglinide Deferasirox Exjade Increased repaglinide plasma concentrations Details Repaglinide Empagliflozin Glyxambi® (as a combination product containing Empagliflozin and Linagliptin) An increased risk of hypoglycemia Details Repaglinide Enalapril Epaned An increased risk of hypoglycemia Details Repaglinide Encorafenib Braftovi Increased OATP1B1 substrate exposure, increased OATP1B3 substrate exposure, increased risk of OATP1B1 substrate-related toxicities... Details Repaglinide Esmolol Brevibloc Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Repaglinide Exenatide Injection Bydureon Increased risk of hypoglycemia Details Repaglinide Finerenone Kerendia Increased CYP2C8 substrate exposure and an increased risk of CYP2C8 substrate-related adverse effects Details Repaglinide Fosinopril Monopril® An increased risk of hypoglycemia Details Repaglinide Labetalol Normodyne® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Repaglinide Levobunolol Ophthalmic AKBeta® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Repaglinide Levothyroxine Ermeza Worsening of glycemic control Details Repaglinide Linagliptin Tradjenta An increased risk of hypoglycemia Details Repaglinide Linezolid Injection Zyvox An increased risk of hypoglycemia Details Repaglinide Liraglutide Injection Saxenda An increased risk of hypoglycemia Details Repaglinide Metformin Fortamet® An increased risk of hypoglycemia Details Repaglinide Mitapivat Aqvesme Reduced CYP2C8 substrate exposure Details Repaglinide Moexipril Univasc® An increased risk of hypoglycemia Details Repaglinide Nadolol Corgard Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Repaglinide Nebivolol Bystolic Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Repaglinide Penbutolol Levatol® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Repaglinide Perindopril Aceon An increased risk of hypoglycemia Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.