Ribociclib

140 interactions 12 explained in plain English
Also sold as: Kisqali
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Lurasidone Lovastatin Ketoconazole Topical Dihydroergotamine Injection Finerenone Lefamulin
11 Contraindicated 126 Major 3 Moderate
All (140) Contraindicated (11) Major (126) Moderate (3)

Contraindicated

Ribociclib Colchicine Colcrys Explained Increased colchicine exposure and an increased risk of fatal toxicity Details Ribociclib Simvastatin Flolipid Explained Increased simvastatin exposure and an increased the risk of myopathy and rhabdomyolysis Details Ribociclib Dihydroergotamine Injection DHE-45® Injection Increased dihydroergotamine exposure and an increased risk of dihydroergotamine-related adverse effects Details Ribociclib Dihydroergotamine Nasal Spray Migranal Increased dihydroergotamine exposure and an increased risk of dihydroergotamine-related adverse effects Details Ribociclib Finerenone Kerendia Increased finerenone exposure and an increased risk of finerenone-related adverse effects Details Ribociclib Ivabradine Corlanor Increased ivabradine exposure, an increased risk of ivabradine-related adverse effects and an increased risk of QT prolongation Details Ribociclib Ketoconazole Topical Extina® Foam Increased ribociclib exposure, an increased risk of ribociclib-related adverse reaction, an increased ketoconazole exposure, an in... Details Ribociclib Lefamulin Xenleta Increased lefamulin exposure, an increased risk of lefamulin-related adverse reactions, an increased sensitive CYP3A4 substrate ex... Details Ribociclib Lovastatin Altocor® Increased lovastatin exposure and an increased risk of myopathy or rhabdomyolysis Details Ribociclib Lurasidone Latuda Increased lurasidone exposure Details Ribociclib Naloxegol Movantik Increased naloxegol exposure and an increased risk of naloxegol-related adverse effects Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.