Safinamide

Contraindicated

Safinamide Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of serotonin syndrome Details Safinamide Amitriptyline Elavil Explained Increased risk of serotonin syndrome Details Safinamide Sertraline Explained An increased risk of serotonin syndrome (hypertension, tachycardia, hyperthermia, myoclonus, mental status changes) Details Safinamide Buprenorphine Belbuca Explained Increased risk of serotonin syndrome Details Safinamide Butorphanol Injection Butorphic Increased risk of serotonin syndrome Details Safinamide Butorphanol Nasal Spray Stadol® NS Increased risk of serotonin syndrome Details Safinamide Deutetrabenazine Austedo Hypertensive crisis (headache, hyperpyrexia, hypertension) Details Safinamide Fentanyl Transdermal Patch Duragesic® Increased risk of serotonin syndrome Details Safinamide Hydromorphone Injection Dilaudid Increased risk of serotonin syndrome Details Safinamide Hydromorphone Rectal available generically Increased risk of serotonin syndrome Details Safinamide Linezolid Injection Zyvox Increased risk of hypertensive crisis Details Safinamide Maprotiline Ludiomil® Increased risk of serotonin syndrome Details Safinamide Methyldopa Aldomet® Hypertensive crisis (headache, palpitation, neck stiffness) Details Safinamide Methylphenidate Adhansia XR® An increased risk of hypertensive crisis (headache, palpitation, and neck stiffness) Details Safinamide Methylphenidate Transdermal Patch Daytrana An increased risk of hypertensive crisis (headache, palpitation, and neck stiffness) Details Safinamide Morphine Injection Astramorph® PF Increased risk of serotonin syndrome Details Safinamide Nalbuphine Injection Nubain® Increased risk of serotonin syndrome Details

Major

Safinamide Albuterol Oral Inhalation Accuneb® Explained An increased risk of cardiovascular adverse effects Details Safinamide Atogepant Qulipta Reduced atogepant exposure Details Safinamide Cariprazine Vraylar Explained Effects on the cariprazine exposure has not been evaluated and the net effect is unclear Details Safinamide Amlodipine Amvaz® Reduced amLODIPine exposure Details Safinamide Atropine Ophthalmic Atropine Care 1% Potential to cause hypertensive crisis Details Safinamide Granisetron Transdermal Patch Sancuso Increased risk of serotonin syndrome Details Safinamide Granisetron Injection Granisol Increased risk of serotonin syndrome Details Safinamide Hydroxychloroquine Plaquenil An increased risk of seizures Details Safinamide Levodopa Oral Inhalation Inbrija Increased risk of levodopa adverse effects, including severe orthostatic hypotension Details Safinamide Lithium Carbonate Lithobid Increased risk of serotonin syndrome Details Safinamide Lumateperone Caplyta Reduced lumateperone exposure Details Safinamide Metoclopramide Injection Gimoti Diminished effectiveness of metoclopramide and the dopaminergic agent Details Safinamide Metoclopramide Nasal Spray Gimoti Diminished effectiveness of metoclopramide and the dopaminergic agent Details Safinamide Nifedipine Adalat® Reduced NIFEdipine exposure Details Safinamide Olodaterol Oral Inhalation Striverdi Potentiated cardiovascular effects Details Safinamide Palonosetron Injection Aloxi® An increased risk of serotonin syndrome Details

Moderate

Safinamide Acarbose Prandase® Explained An increased risk of hypoglycemia Details Safinamide Glimepiride Amaryl An increased risk of hypoglycemia Details Safinamide Glipizide Glucotrol An increased risk of hypoglycemia Details Safinamide Hydrocortisone Ala-Cort Reduced hydrocortisone exposure Details Safinamide Hydrocortisone Injection A-Hydrocort® Reduced hydrocortisone exposure Details Safinamide Insulin Degludec (Rdna Origin) Injection Ryzodeg® (as a combination product containing Insulin Degludec and Insulin Aspart) An increased risk of hypoglycemia Details Safinamide Insulin Detemir (Rdna Origin) Injection Levemir An increased risk of hypoglycemia Details