Salsalate

89 interactions 5 explained in plain English
Also sold as: Disalcid Disalcid®
About Salsalate

Salsalate is used to relieve pain, tenderness, swelling, and stiffness caused by rheumatoid arthritis (arthritis caused by swelling of the lining of the joints), osteoarthritis (arthritis caused by a breakdown of the lining of the joints), and other conditions that cause swelling. Salsalate is in a class of nonsteroida… Read the full Salsalate drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Ketorolac Injection Ketorolac Nasal Spray Ketorolac Ophthalmic Pemetrexed Injection Aspirin
4 Contraindicated 53 Major 32 Moderate
All (89) Contraindicated (4) Major (53) Moderate (32)

Contraindicated

Salsalate Ketorolac Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Salsalate Ketorolac Injection Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Salsalate Ketorolac Nasal Spray Sprix Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Salsalate Ketorolac Ophthalmic Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details

Major

Salsalate Amitriptyline Elavil Explained An increased risk of bleeding Details Salsalate Sertraline Explained An increased risk of bleeding Details Salsalate Apixaban Eliquis Explained An increased risk of bleeding and can cause serious, potentially fatal bleeding Details Salsalate Aspirin Acuprin® An increased risk of bleeding, decreased renal function, and an increased risk of gastrointestinal adverse events Details Salsalate Aspirin Rectal Aspirin An increased risk of bleeding, decreased renal function, and an increased risk of gastrointestinal adverse events Details Salsalate Betrixaban Bevyxxa® An increased risk of bleeding Details Salsalate Anagrelide Agrylin An increased risk of bleeding Details Salsalate Bromfenac Ophthalmic Bromday® Increased risk of bleeding Details Salsalate Budesonide Entocort Increased risk of gastrointestinal ulcer or bleeding Details Salsalate Budesonide Nasal Spray Rhinocort Increased risk of gastrointestinal ulcer or bleeding Details Salsalate Budesonide Oral Inhalation Pulmicort Increased risk of gastrointestinal ulcer or bleeding Details Salsalate Clopidogrel Plavix An increased risk of bleeding Details Salsalate Cyclosporine Injection Atopica An increased risk of cycloSPORINE nephrotoxicity Details Salsalate Cyclosporine Ophthalmic Cequa An increased risk of cycloSPORINE nephrotoxicity Details Salsalate Dalteparin Injection Fragmin An increased risk of bleeding Details Salsalate Deflazacort Emflaza Increased risk of gastrointestinal ulcer or bleeding Details Salsalate Dexamethasone Injection Decadron Increased risk of gastrointestinal ulcer or bleeding Details Salsalate Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Increased risk of gastrointestinal ulcer or bleeding Details Salsalate Diclofenac Ophthalmic Voltaren® Eye Drops Increased risk of bleeding Details Salsalate Diclofenac Topical (Actinic Keratosis) Pennsaid Increased risk of bleeding Details Salsalate Diclofenac Topical (Arthritis Pain) Pennsaid® Increased risk of bleeding Details Salsalate Diclofenac Transdermal Patch Flector Increased risk of bleeding Details Salsalate Digoxin Cardoxin® Increased digoxin exposure and prolonged half-life of digoxin Details Salsalate Dipyridamole Permole® An increased risk of bleeding Details Salsalate Edoxaban Savaysa Increased risk of bleeding Details Salsalate Emtricitabine Emtriva Increased emtricitabine exposure and an increased risk of emtricitabine-related adverse effects Details Salsalate Enoxaparin Lovenox An increased risk of bleeding Details Salsalate Enoxaparin Injection Lovenox An increased risk of bleeding Details Salsalate Epoprostenol Flolan An increased risk of bleeding Details Salsalate Etodolac Lodine Increased risk of bleeding Details Salsalate Fenoprofen Fenopron Increased risk of bleeding Details Salsalate Flurbiprofen Ansaid Increased risk of bleeding Details Salsalate Flurbiprofen Ophthalmic Ocufen Increased risk of bleeding Details Salsalate Furosemide Injection Disal An increased risk of salicylate toxicity and reduced diuretic effectiveness and possible nephrotoxicity Details Salsalate Hydrocortisone Ala-Cort Increased risk of gastrointestinal ulcer or bleeding Details Salsalate Hydrocortisone Injection A-Hydrocort® Increased risk of gastrointestinal ulcer or bleeding Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.