Salsalate
89 interactions 5 explained in plain EnglishSalsalate is used to relieve pain, tenderness, swelling, and stiffness caused by rheumatoid arthritis (arthritis caused by swelling of the lining of the joints), osteoarthritis (arthritis caused by a breakdown of the lining of the joints), and other conditions that cause swelling. Salsalate is in a class of nonsteroida… Read the full Salsalate drug information page →
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Major
Salsalate Ibuprofen Addaprin An increased risk of gastrointestinal toxicity Details Salsalate Iloprost Aurlumyn An increased risk of bleeding Details Salsalate Ketoprofen Actron® Increased risk of bleeding Details Salsalate Lithium Carbonate Lithobid Increased lithium exposure and an increased risk of lithium toxicity Details Salsalate Meclofenamate Meclodium® Increased risk of bleeding Details Salsalate Mefenamic Acid Ponstel® Increased risk of bleeding Details Salsalate Meloxicam Alloxate An increased risk of gastrointestinal toxicity and an increased risk of bleeding Details Salsalate Meloxicam Injection Alloxate An increased risk of gastrointestinal toxicity and an increased risk of bleeding Details Salsalate Melphalan Alkeran An increased risk of bleeding Details Salsalate Melphalan Injection Alkeran An increased risk of bleeding Details Salsalate Mesalamine Apriso Increased risk of bleeding Details Salsalate Mesalamine Rectal Canasa Increased risk of bleeding Details Salsalate Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Salsalate Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Salsalate Nabumetone Relafen Increased risk of bleeding Details Salsalate Naproxen Aleve Increased risk of bleeding Details Salsalate Pemetrexed Injection Alimta Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... DetailsModerate
Salsalate Lisinopril Prinivil Explained Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Salsalate Acetazolamide Diamox® Sequels® Metabolic acidosis and CNS toxicity (lethargy, confusion, urinary incontinence) Details Salsalate Atenolol Tenormin Explained Reduced antihypertensive effect Details Salsalate Acebutolol Sectral® Reduced antihypertensive effect Details Salsalate Benazepril Lotensin Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Salsalate Azilsartan Edarbi Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Salsalate Betaxolol Betoptic S Reduced antihypertensive effect Details Salsalate Betaxolol Ophthalmic Betoptic® Reduced antihypertensive effect Details Salsalate Bisoprolol Zebeta® Reduced antihypertensive effect Details Salsalate Captopril Capoten® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Salsalate Desmopressin Nasal Concentraid® Increased risk of water intoxication with hyponatremia Details Salsalate Enalapril Epaned Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Salsalate Eprosartan Teveten® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Salsalate Esmolol Brevibloc Reduced antihypertensive effect Details Salsalate Fosinopril Monopril® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Salsalate Insulin Degludec (Rdna Origin) Injection Ryzodeg® (as a combination product containing Insulin Degludec and Insulin Aspart) Increased risk of hypoglycemia Details Salsalate Insulin Detemir (Rdna Origin) Injection Levemir Increased risk of hypoglycemia Details Salsalate Insulin Glulisine (Rdna Origin) Injection Apidra Increased risk of hypoglycemia Details Salsalate Irbesartan Avapro Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Salsalate Labetalol Normodyne® Reduced antihypertensive effect Details Salsalate Levobunolol Ophthalmic AKBeta® Reduced antihypertensive effect Details Salsalate Levofloxacin Levaquin An increased risk of seizures Details Salsalate Levofloxacin Injection Levaquin An increased risk of seizures DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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