Salsalate

Name: Salsalate Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

89 interactions 5 explained in plain English

Also sold as: Disalcid Disalcid®

About Salsalate

Salsalate is used to relieve pain, tenderness, swelling, and stiffness caused by rheumatoid arthritis (arthritis caused by swelling of the lining of the joints), osteoarthritis (arthritis caused by a breakdown of the lining of the joints), and other conditions that cause swelling. Salsalate is in a class of nonsteroida… Read the full Salsalate drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Ketorolac Injection Ketorolac Nasal Spray Ketorolac Ophthalmic Pemetrexed Injection Aspirin

4 Contraindicated 53 Major 32 Moderate

All (89) Contraindicated (4) Major (53) Moderate (32)

Moderate

Salsalate Losartan Arbli Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Salsalate Moexipril Univasc® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Salsalate Nadolol Corgard Reduced antihypertensive effect Details Salsalate Nebivolol Bystolic Reduced antihypertensive effect Details Salsalate Ofloxacin Floxin® An increased risk of seizures Details Salsalate Ofloxacin Ophthalmic Ocuflox An increased risk of seizures Details Salsalate Ofloxacin Otic Floxin® Otic An increased risk of seizures Details Salsalate Penbutolol Levatol® Reduced antihypertensive effect Details Salsalate Perindopril Aceon Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.