Serdexmethylphenidate and Linezolid Injection: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Linezolid Injection
Serdexmethylphenidate
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased risk of hypertensive crisis (palpitations, headache, flushing, and sweating)
Interaction Deep Dive
Concomitant use of serdexmethylphenidate, a prodrug of dexmethylphenidate, with MAOIs or within 14 days after discontinuing MAOI treatment is contraindicated. Coadministration can cause hypertensive crisis. Potential outcomes include death, stroke, myocardial infarction, aortic dissection, ophthalmological complications, eclampsia, pulmonary edema, and renal failure1.
Why it happens (mechanism)
Unknown
Common questions
Can I take Serdexmethylphenidate and Linezolid Injection together?
Increased risk of hypertensive crisis (palpitations, headache, flushing, and sweating) Always confirm with your pharmacist or prescriber before making any change.
How serious is the Serdexmethylphenidate and Linezolid Injection interaction?
It is rated contraindicated. These should generally not be used together.
How quickly could this interaction happen?
The documented onset is "rapid". Effects can appear quickly, often within about 24 hours of combining the drugs.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Serdexmethylphenidate or Linezolid Injection need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: AZSTARYS(TM) oral capsules, serdexmethylphenidate dexmethylphenidate oral capsules. Corium LLC (per FDA), Boston, MA, 2023. DailyMed
Keep reading about Linezolid Injection
Keep reading about Serdexmethylphenidate
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