Sertraline and Lasmiditan: Interaction Details
AI-assisted, pharmacist-reviewed · AI content regenerated Jul 11, 2026 · Source data updated Jul 2, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Lasmiditan
Sertraline
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
You've been prescribed lasmiditan (Reyvow) for migraines while also taking sertraline, an antidepressant. Both of these medicines raise levels of a brain chemical called serotonin. When two serotonin-boosting drugs are combined, there's a small chance of too much serotonin building up, which is called serotonin syndrome.
Warning signs can include a fast or pounding heart, high fever, sweating, shakiness or muscle twitching, agitation, or confusion. This is considered a theoretical risk, meaning it's a caution rather than something known to happen often. The good news is your care team can manage this by keeping an eye on how you feel. Keep taking both as prescribed, and let your doctor or pharmacist know if you notice any of these symptoms.
Effect: Additive serotonergic activity may increase the risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, autonomic instability, altered mental status).
Mechanism: Lasmiditan is a 5-HT1F receptor agonist; sertraline is an SSRI. Combined serotonergic effect is additive (PD interaction), not a metabolic/PK interaction.
- Direction: Increased serotonergic burden.
- Onset: Unspecified.
- Evidence: Theoretical.
- Severity: Major.
Management: Use lasmiditan with caution in patients on serotonergic agents. Monitor for signs/symptoms of serotonin syndrome. Discontinue lasmiditan (and re-evaluate serotonergic therapy) if serotonin syndrome is suspected.
What happens
Increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes)
Interaction Deep Dive
As a serotonin agonist, lasmiditan carries a heightened potential for serotonin syndrome when given together with another serotonergic drug. Exercise caution when lasmiditan is used in patients receiving agents that raise serotonin levels, and stop lasmiditan if serotonin syndrome is suspected1.
Why it happens (mechanism)
Additive serotonergic effects
How to manage this interaction
Your care team can manage this combination safely, and it is often used together when a migraine medicine is needed.
- Keep taking both as prescribed unless your doctor tells you otherwise. Do not stop either on your own.
- Your team may monitor you more closely, especially when starting lasmiditan or after a dose.
- Know the warning signs: fast heartbeat, fever, heavy sweating, muscle twitching or stiffness, shivering, agitation, or confusion.
- Get medical help promptly if these appear, and mention you take both medicines.
Ask your pharmacist or prescriber if you have questions or take other serotonergic drugs.
Management is individual — confirm any change with your pharmacist or prescriber.
Common questions
Can I take Sertraline and Lasmiditan together?
Combining lasmiditan and sertraline can theoretically raise the risk of serotonin syndrome; keep taking both as prescribed but watch for symptoms like fever, fast heartbeat, muscle twitching, or confusion and seek help if they occur. Always confirm with your pharmacist or prescriber before making any change.
How serious is the Sertraline and Lasmiditan interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How is the Sertraline and Lasmiditan interaction managed?
Your care team can manage this combination safely, and it is often used together when a migraine medicine is needed. Keep taking both as prescribed unless your doctor tells you otherwise. Do not stop either on your own. Your team may monitor you more closely, especially when starting lasmiditan or after a dose. Know the warning signs: fast heartbeat, fever, heavy sweating, muscle twitching or stif… Management is individual — always follow your own care team's guidance.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
From our Q&A
Real reader questions about these medications, each personally answered by our pharmacist:
Questions for your pharmacist
- Does my dose of Sertraline or Lasmiditan need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: REYVOW(TM) oral tablets, lasmiditan oral tablets. Lilly USA LLC (per manufacturer), Indianapolis, IN, 2019. DailyMed
Keep reading about Lasmiditan
Keep reading about Sertraline
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