Sorafenib and Docetaxel Injection: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Sorafenib
Docetaxel Injection
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased docetaxel exposure and plasma concentrations
Interaction Deep Dive
Coadministration of docetaxel (75 milligrams (mg) or 100 milligrams/square meter every 21 days) and sorafenib (200 mg or 400 mg twice daily), with a 3-day break in dosing around docetaxel, led to a 36%-80% increase in docetaxel AUC and a 16%-32% increase in docetaxel Cmax. Caution is advised when these two agents are coadministered1. Patients should be monitored for signs/symptoms of docetaxel adverse events (anemia, leukopenia, diarrhea, mucositis).
Why it happens (mechanism)
Unknown
Common questions
Can I take Sorafenib and Docetaxel Injection together?
Increased docetaxel exposure and plasma concentrations Always confirm with your pharmacist or prescriber before making any change.
How serious is the Sorafenib and Docetaxel Injection interaction?
It is rated moderate. Can be significant — usually manageable with monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
Questions for your pharmacist
- Does my dose of Sorafenib or Docetaxel Injection need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there anything you'd monitor while I'm on both?
References (1)
- Product Information: NEXAVAR(R) oral tablets, sorafenib oral tablets. Bayer Pharmaceuticals Corporation, West Haven, CT, 2007. DailyMed
Keep reading about Sorafenib
Keep reading about Docetaxel Injection
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
Check another combination
Our instant two-drug interaction checker is almost here.
Still have questions about this combination?
Every question gets a real answer from a licensed pharmacist — free, and usually within a day.
Ask the pharmacist