Stiripentol and Amlodipine: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Stiripentol
Amlodipine
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased amLODIPine exposure and an increased risk of hypotension and edema
Interaction Deep Dive
Coadministration of amLODIPine with moderate and strong CYP3A inhibitors results in increased systemic exposure to amLODIPine. Dose reduction of amLODIPine may be required if symptoms of hypotension and edema occur with coadministration of CYP3A inhibitors. In a pharmacokinetic study of elderly hypertensive patients, coadministration of dilTIAZem (a CYP3A inhibitor) with amLODIPine resulted in a 60% increase in amLODIPine systemic exposure32. Monitor for symptoms of hypotension and edema when amLODIPine is coadministered with CYP3A inhibitors to determine the need for dose adjustment 21.
Why it happens (mechanism)
Inhibition of CYP3A-mediated metabolism of amLODIPine
Literature reports
2 reports — tap to read
a) In a pharmacokinetic study of elderly hypertensive patients, coadministration of dilTIAZem (a CYP3A inhibitor) 180 mg daily with amLODIPine 5 mg resulted in a 60% increase in amLODIPine systemic exposure 231.
b) Erythromycin (CYP3A inhibitor) coadministration in healthy volunteers did not significantly change amLODIPine systemic exposure. However, strong inhibitors of CYP3A (e.g., itraconazole, clarithromycin) may increase amLODIPine exposure to a greater extent 1.
Common questions
Can I take Stiripentol and Amlodipine together?
Increased amLODIPine exposure and an increased risk of hypotension and edema Always confirm with your pharmacist or prescriber before making any change.
How serious is the Stiripentol and Amlodipine interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
From our Q&A
Real reader questions about these medications, each personally answered by our pharmacist:
Questions for your pharmacist
- Does my dose of Stiripentol or Amlodipine need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (3)
- Product Information: SDAMLO oral solution, amlodipine oral solution. Brillian Pharma Inc. (per FDA), Edison, NJ, 2025. DailyMed
- Product Information: WIDAPLIK(TM) oral tablets, telmisartan amlodipine indapamide oral tablets. George Medicines Pty Limited (per FDA), Pithampur, Pradesh, India, 2025. DailyMed
- Product Information: EXFORGE oral tablets, amlodipine valsartan oral tablets. Novartis Pharmaceuticals Corporation (per FDA), East Hanover, NJ, 2019. DailyMed
Keep reading about Stiripentol
Keep reading about Amlodipine
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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