Sulindac

94 interactions 5 explained in plain English
Also sold as: Clinoril®
About Sulindac

Sulindac is an NSAID pain reliever used to treat arthritis, bursitis, tendinitis, and gout. Read the full Sulindac drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Ophthalmic Ketorolac Nasal Spray Ketorolac Injection Ketorolac Pemetrexed Injection Melphalan Injection
4 Contraindicated 61 Major 28 Moderate 1 Minor
All (94) Contraindicated (4) Major (61) Moderate (28) Minor (1)

Contraindicated

Sulindac Ketorolac Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Sulindac Ketorolac Injection Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Sulindac Ketorolac Nasal Spray Sprix Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Sulindac Ketorolac Ophthalmic Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details

Major

Sulindac Amitriptyline Elavil Explained An increased risk of bleeding Details Sulindac Sertraline Explained An increased risk of bleeding Details Sulindac Apixaban Eliquis Explained An increased risk of bleeding Details Sulindac Aspirin Acuprin® An increased risk of bleeding, decreased renal function, and an increased risk of gastrointestinal adverse events Details Sulindac Aspirin Rectal Aspirin An increased risk of bleeding, decreased renal function, and an increased risk of gastrointestinal adverse events Details Sulindac Azathioprine Azasan An increased risk of hepatotoxicity Details Sulindac Betrixaban Bevyxxa® An increased risk of bleeding Details Sulindac Anagrelide Agrylin An increased risk of bleeding Details Sulindac Bromfenac Ophthalmic Bromday® Increased risk of bleeding Details Sulindac Budesonide Entocort Increased risk of gastrointestinal ulcer or bleeding Details Sulindac Budesonide Nasal Spray Rhinocort Increased risk of gastrointestinal ulcer or bleeding Details Sulindac Budesonide Oral Inhalation Pulmicort Increased risk of gastrointestinal ulcer or bleeding Details Sulindac Clopidogrel Plavix An increased risk of bleeding Details Sulindac Cyclosporine Injection Atopica An increased risk of cycloSPORINE nephrotoxicity Details Sulindac Cyclosporine Ophthalmic Cequa An increased risk of cycloSPORINE nephrotoxicity Details Sulindac Dabigatran Pradaxa® An increased risk of bleeding Details Sulindac Dabigatran Etexilate An increased risk of bleeding Details Sulindac Dalteparin Injection Fragmin An increased risk of bleeding Details Sulindac Deflazacort Emflaza Increased risk of gastrointestinal ulcer or bleeding Details Sulindac Dexamethasone Injection Decadron Increased risk of gastrointestinal ulcer or bleeding Details Sulindac Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Increased risk of gastrointestinal ulcer or bleeding Details Sulindac Diclofenac Ophthalmic Voltaren® Eye Drops Increased risk of bleeding Details Sulindac Diclofenac Topical (Actinic Keratosis) Pennsaid Increased risk of bleeding Details Sulindac Diclofenac Topical (Arthritis Pain) Pennsaid® Increased risk of bleeding Details Sulindac Diclofenac Transdermal Patch Flector Increased risk of bleeding Details Sulindac Digoxin Cardoxin® Increased digoxin exposure and prolonged half-life of digoxin Details Sulindac Dipyridamole Permole® An increased risk of bleeding Details Sulindac Edoxaban Savaysa An increased risk of bleeding Details Sulindac Emtricitabine Emtriva Increased emtricitabine exposure and an increased risk of emtricitabine-related adverse effects Details Sulindac Enoxaparin Lovenox An increased risk of bleeding Details Sulindac Enoxaparin Injection Lovenox An increased risk of bleeding Details Sulindac Epoprostenol Flolan An increased risk of bleeding Details Sulindac Etodolac Lodine Increased risk of bleeding Details Sulindac Fenoprofen Fenopron Increased risk of bleeding Details Sulindac Flurbiprofen Ansaid Increased risk of bleeding Details Sulindac Flurbiprofen Ophthalmic Ocufen Increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.