Sultamicillin

24 interactions 1 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 11, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Demeclocycline Methotrexate Minocycline Topical Estradiol Estradiol Topical Estradiol Transdermal Patch
13 Major 5 Moderate 6 Minor
All (24) Major (13) Moderate (5) Minor (6)

Major

Sultamicillin Demeclocycline Declomycin® Decreased antibacterial effectiveness Details Sultamicillin Doxycycline Injection Acticlate Decreased antibacterial effectiveness Details Sultamicillin Eravacycline Injection Xerava Decreased antibacterial effectiveness Details Sultamicillin Estradiol Delestrogen Decreased contraceptive effectiveness Details Sultamicillin Estradiol Topical Divigel Decreased contraceptive effectiveness Details Sultamicillin Estradiol Transdermal Patch Alora® Decreased contraceptive effectiveness Details Sultamicillin Hydroxychloroquine Plaquenil An increased risk of seizures Details Sultamicillin Levonorgestrel After banger Decreased contraceptive effectiveness Details Sultamicillin Levonorgestrel Intrauterine System Kyleena Decreased contraceptive effectiveness Details Sultamicillin Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Sultamicillin Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Sultamicillin Minocycline Amzeeq Decreased antibacterial effectiveness Details Sultamicillin Minocycline Topical Amzeeq Decreased antibacterial effectiveness Details

Moderate

Sultamicillin Dexlansoprazole Dexilant Reduced ampicillin bioavailability Details Sultamicillin Entacapone Comtan An increased risk of enhanced entacapone adverse effects (diarrhea, dyskinesias) Details Sultamicillin Lansoprazole Prevacid Loss of ampicillin efficacy Details Sultamicillin Lanthanum Fosrenol® Reduced ampicillin bioavailability Details Sultamicillin Lixisenatide Injection Adlyxin® Delayed therapeutic effect Details

Minor

Sultamicillin Amikacin Injection Amikin® Loss of aminoglycoside efficacy Details Sultamicillin Amikacin Oral Inhalation Arikayce Loss of aminoglycoside efficacy Details Sultamicillin Atenolol Tenormin Explained Decreased atenolol effectiveness Details Sultamicillin Gentamicin Injection Garamycin® I.V. Loss of aminoglycoside efficacy Details Sultamicillin Gentamicin Ophthalmic Garamycin® Ophthalmic Loss of aminoglycoside efficacy Details Sultamicillin Gentamicin Topical Garamycin® Loss of aminoglycoside efficacy Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.