Sultamicillin
24 interactions 1 explained in plain English
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 11, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Demeclocycline
Methotrexate
Minocycline Topical
Estradiol
Estradiol Topical
Estradiol Transdermal Patch
Major
Sultamicillin Demeclocycline Declomycin® Decreased antibacterial effectiveness Details Sultamicillin Doxycycline Injection Acticlate Decreased antibacterial effectiveness Details Sultamicillin Eravacycline Injection Xerava Decreased antibacterial effectiveness Details Sultamicillin Estradiol Delestrogen Decreased contraceptive effectiveness Details Sultamicillin Estradiol Topical Divigel Decreased contraceptive effectiveness Details Sultamicillin Estradiol Transdermal Patch Alora® Decreased contraceptive effectiveness Details Sultamicillin Hydroxychloroquine Plaquenil An increased risk of seizures Details Sultamicillin Levonorgestrel After banger Decreased contraceptive effectiveness Details Sultamicillin Levonorgestrel Intrauterine System Kyleena Decreased contraceptive effectiveness Details Sultamicillin Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Sultamicillin Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Sultamicillin Minocycline Amzeeq Decreased antibacterial effectiveness Details Sultamicillin Minocycline Topical Amzeeq Decreased antibacterial effectiveness DetailsNo interactions on this page match that filter — try the next page or clear the filter.
Check another drug
Still have questions about this combination?
Every question gets a real answer from a licensed pharmacist — free, and usually within a day.
Ask the pharmacistEducational information only, not medical advice. Always confirm interactions with your pharmacist
or prescriber before making any change to your medications.