Tacrolimus

157 interactions 13 explained in plain English
Also sold as: Astagraf Astagraf XL® Envarsus Envarsus XR® Prograf Prograf®
About Tacrolimus

Tacrolimus is an immunosuppressant used to prevent the immune system from rejecting transplanted organs. Read the full Tacrolimus drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketoconazole Topical Lefamulin Lenacapavir Injection Dasatinib Sertraline Perindopril
2 Contraindicated 150 Major 5 Moderate
All (157) Contraindicated (2) Major (150) Moderate (5)

Major

Tacrolimus Cyclosporine Injection Atopica Increased tacrolimus exposure and an increased risk of nephrotoxicity Details Tacrolimus Cyclosporine Ophthalmic Cequa Increased tacrolimus exposure and an increased risk of nephrotoxicity Details Tacrolimus Dabigatran Pradaxa® Increased dabigatran etexilate exposure Details Tacrolimus Dabigatran Etexilate Increased dabigatran etexilate exposure Details Tacrolimus Danazol Danocrine® Increased tacrolimus exposure and an increased risk of toxicity Details Tacrolimus Dasatinib Phyrago An increased risk of QT interval prolongation Details Tacrolimus Degarelix Injection Firmagon Increased risk of QT interval prolongation Details Tacrolimus Deutetrabenazine Austedo An increased risk of QT interval prolongation Details Tacrolimus Dexamethasone Injection Decadron Reduced tacrolimus exposure Details Tacrolimus Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Reduced tacrolimus exposure Details Tacrolimus Diclofenac Ophthalmic Voltaren® Eye Drops Acute renal failure Details Tacrolimus Diclofenac Topical (Actinic Keratosis) Pennsaid Acute renal failure Details Tacrolimus Diclofenac Topical (Arthritis Pain) Pennsaid® Acute renal failure Details Tacrolimus Diclofenac Transdermal Patch Flector Acute renal failure Details Tacrolimus Didanosine Videx® An increased risk of nephrotoxicity Details Tacrolimus Disopyramide Norpace An increased risk of QT interval prolongation Details Tacrolimus Dofetilide Tikosyn An increased risk of QT interval prolongation Details Tacrolimus Dolasetron Anzemet An increased risk of QT interval prolongation Details Tacrolimus Dolasetron Injection Anzemet An increased risk of QT interval prolongation Details Tacrolimus Edoxaban Savaysa Increased edoxaban exposure Details Tacrolimus Elacestrant Orserdu Increased P-gp substrate exposure and an increased risk of P-gp substrate-related adverse effects Details Tacrolimus Emtricitabine Emtriva An increased risk of nephrotoxicity Details Tacrolimus Enalapril Epaned An increased risk of hyperkalemia Details Tacrolimus Enasidenib Idhifa Reduced CYP3A substrate exposure and reduced efficacy of CYP3A substrate Details Tacrolimus Encorafenib Braftovi Reduced CYP3A4 substrate exposure, reduced efficacy of CYP3A4 substrate and an increased risk of QT interval prolongation Details Tacrolimus Eprosartan Teveten® An increased risk of hyperkalemia Details Tacrolimus Erdafitinib Balversa Increased P-gp substrate exposure and an increased risk of P-gp substrate-related adverse effects Details Tacrolimus Eribulin Injection Halaven An increased risk of QT interval prolongation Details Tacrolimus Esomeprazole Nexium Increased tacrolimus exposure Details Tacrolimus Esomeprazole Injection Nexium Increased tacrolimus exposure Details Tacrolimus Etodolac Lodine Acute renal failure Details Tacrolimus Famotidine Calmicid An increased risk of QT interval prolongation Details Tacrolimus Famotidine Injection Calmicid An increased risk of QT interval prolongation Details Tacrolimus Felbamate Felbatol An increased risk of QT interval prolongation Details Tacrolimus Felodipine Plendil® Increased tacrolimus exposure Details Tacrolimus Fenoprofen Fenopron Acute renal failure Details Tacrolimus Fentanyl Transdermal Patch Duragesic® Decreased tacrolimus clearance Details Tacrolimus Flecainide Tambocor® An increased risk of QT interval prolongation Details Tacrolimus Flurbiprofen Ansaid Acute renal failure Details Tacrolimus Flurbiprofen Ophthalmic Ocufen Acute renal failure Details

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