Tacrolimus

157 interactions 13 explained in plain English

Also sold as: Astagraf Astagraf XL® Envarsus Envarsus XR® Prograf Prograf®

About Tacrolimus

Tacrolimus is an immunosuppressant used to prevent the immune system from rejecting transplanted organs. Read the full Tacrolimus drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketoconazole Topical Lefamulin Lenacapavir Injection Dasatinib Sertraline Perindopril

2 Contraindicated 150 Major 5 Moderate

All (157) Contraindicated (2) Major (150) Moderate (5)

Contraindicated

Tacrolimus Ketoconazole Topical Extina® Foam Increased tacrolimus exposure and an increased risk of QT interval prolongation Details Tacrolimus Lefamulin Xenleta Increased sensitive CYP3A4 substrates exposure and an increased risk of QT interval prolongation Details

Major

Tacrolimus Abacavir Ziagen Explained An increased risk of nephrotoxicity Details Tacrolimus Abametapir Explained Increased exposure of CYP3A4 substrate Details Tacrolimus Omeprazole Gastrobim Explained Increased tacrolimus exposure and an increased risk of toxicity Details Tacrolimus Amitriptyline Elavil Explained An increased risk of QT interval prolongation Details Tacrolimus Sertraline Explained An increased risk of QT interval prolongation Details Tacrolimus Lisinopril Prinivil Explained An increased risk of hyperkalemia Details Tacrolimus Buprenorphine Belbuca Explained An increased risk of QT interval prolongation Details Tacrolimus Relugolix Orgovyx Explained Increased risk of QT interval prolongation Details Tacrolimus Colchicine Colcrys Explained Increased colchicine plasma concentrations and increased risk of toxicity Details Tacrolimus Abrocitinib Cibinqo Explained Increased exposure of P-glycoprotein substrate Details Tacrolimus Amikacin Injection Amikin® An increased risk of nephrotoxicity Details Tacrolimus Amikacin Oral Inhalation Arikayce An increased risk of nephrotoxicity Details Tacrolimus Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Tacrolimus Apixaban Eliquis Explained Increased apixaban exposure Details Tacrolimus Arsenic Trioxide Trisenox Increased risk of QT-interval prolongation and torsade de pointes Details Tacrolimus Aripiprazole Injection Abilify An increased risk of QT interval prolongation Details Tacrolimus Arsenic Trioxide Injection Trisenox Increased risk of QT-interval prolongation and torsade de pointes Details Tacrolimus Asciminib Scemblix Increased exposure to CYP3A4/P-gp substrates and increased risk of CYP3A4/P-gp substrates-related adverse effects Details Tacrolimus Asenapine Transdermal Patch Secuado An increased risk of QT interval prolongation Details Tacrolimus Aspirin Acuprin® Acute renal failure Details Tacrolimus Aspirin Rectal Aspirin Acute renal failure Details Tacrolimus Azithromycin AzaSite An increased risk of QT interval prolongation Details Tacrolimus Belumosudil Rezurock Explained Increased P-gp substrate exposure Details Tacrolimus Benazepril Lotensin An increased risk of hyperkalemia Details Tacrolimus Alfuzosin UroXatral An increased risk of QT interval prolongation Details Tacrolimus Amlodipine Amvaz® Increased tacrolimus exposure Details Tacrolimus Amphotericin B Injection Abelcet An increased risk of nephrotoxicity Details Tacrolimus Anagrelide Agrylin Increased risk of QT interval prolongation Details Tacrolimus Azilsartan Edarbi An increased risk of hyperkalemia Details Tacrolimus Bedaquiline Sirturo An increased risk of QT interval prolongation Details Tacrolimus Bromfenac Ophthalmic Bromday® Acute renal failure Details Tacrolimus Captopril Capoten® An increased risk of hyperkalemia Details Tacrolimus Caspofungin Injection Cancidas Reduced tacrolimus exposure Details Tacrolimus Chloramphenicol Injection Chloromycetin® Injection Increased tacrolimus exposure and an increased risk of tacrolimus toxicity Details Tacrolimus Chloroquine Aralen® An increased risk of QT interval prolongation Details Tacrolimus Cisplatin Injection Platinol-AQ® An increased risk of nephrotoxicity Details Tacrolimus Clotrimazole Aardora Anti-Fungal Maximum Strength Increased tacrolimus concentration and an increased risk of toxicity Details Tacrolimus Clotrimazole Lozenge Mycelex® Increased tacrolimus concentration and an increased risk of toxicity Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.