Tacrolimus

Name: Tacrolimus Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

157 interactions 13 explained in plain English

Also sold as: Astagraf Astagraf XL® Envarsus Envarsus XR® Prograf Prograf®

About Tacrolimus

Tacrolimus is an immunosuppressant used to prevent the immune system from rejecting transplanted organs. Read the full Tacrolimus drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketoconazole Topical Lefamulin Lenacapavir Injection Dasatinib Sertraline Perindopril

2 Contraindicated 150 Major 5 Moderate

All (157) Contraindicated (2) Major (150) Moderate (5)

Moderate

Tacrolimus Trospium / Xanomeline Cobenfy Explained Increased oral sensitive CYP3A4 substrate that are P-gp substrates with NTI exposure and an increased risk on severity and frequen... Details Tacrolimus Ertapenem Injection Invanz Increased tacrolimus plasma concentrations Details Tacrolimus Ganciclovir Cytovene® Oral An increased risk of nephrotoxicity Details Tacrolimus Ganciclovir Injection Cytovene® I.V.® An increased risk of nephrotoxicity Details Tacrolimus Ganciclovir Ophthalmic Zirgan An increased risk of nephrotoxicity Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.