Tacrolimus

157 interactions 13 explained in plain English
Also sold as: Astagraf Astagraf XL® Envarsus Envarsus XR® Prograf Prograf®
About Tacrolimus

Tacrolimus is an immunosuppressant used to prevent the immune system from rejecting transplanted organs. Read the full Tacrolimus drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketoconazole Topical Lefamulin Lenacapavir Injection Dasatinib Sertraline Perindopril
2 Contraindicated 150 Major 5 Moderate
All (157) Contraindicated (2) Major (150) Moderate (5)

Major

Tacrolimus Foscarnet Injection Foscavir An increased risk of QT interval prolongation Details Tacrolimus Fosinopril Monopril® An increased risk of hyperkalemia Details Tacrolimus Fostemsavir Rukobia Increased risk of torsade de pointes Details Tacrolimus Galantamine Razadyne An increased risk of QT interval prolongation Details Tacrolimus Gatifloxacin Ophthalmic Zymar® An increased risk of QT interval prolongation Details Tacrolimus Gemifloxacin Factive An increased risk of QT interval prolongation Details Tacrolimus Gentamicin Injection Garamycin® I.V. An increased risk of nephrotoxicity Details Tacrolimus Gentamicin Ophthalmic Garamycin® Ophthalmic An increased risk of nephrotoxicity Details Tacrolimus Gentamicin Topical Garamycin® An increased risk of nephrotoxicity Details Tacrolimus Gilteritinib Xospata Increased P-gp substrate exposure and increased incidence and severity of adverse reactions associated with the P-gp substrate Details Tacrolimus Glasdegib Daurismo Increased risk of QT interval prolongation Details Tacrolimus Goserelin Implant Zoladex Increased risk of QT interval prolongation Details Tacrolimus Granisetron Transdermal Patch Sancuso An increased risk of QT interval prolongation Details Tacrolimus Granisetron Injection Granisol An increased risk of QT interval prolongation Details Tacrolimus Histrelin Implant Supprelin Increased risk of QT interval prolongation Details Tacrolimus Hydroxychloroquine Plaquenil Increased risk of QT interval prolongation Details Tacrolimus Ibuprofen Addaprin Acute renal failure Details Tacrolimus Inotuzumab Ozogamicin Injection Besponsa Increased risk of QT interval prolongation Details Tacrolimus Irbesartan Avapro An increased risk of hyperkalemia Details Tacrolimus Isradipine DynaCirc® Increased tacrolimus exposure Details Tacrolimus Ivabradine Corlanor An increased risk of QT interval prolongation Details Tacrolimus Ketoprofen Actron® Acute renal failure Details Tacrolimus Ketorolac Acular Acute renal failure Details Tacrolimus Ketorolac Injection Acular Acute renal failure Details Tacrolimus Ketorolac Nasal Spray Sprix Acute renal failure Details Tacrolimus Ketorolac Ophthalmic Acular Acute renal failure Details Tacrolimus Lamivudine Epivir An increased risk of nephrotoxicity Details Tacrolimus Lanreotide Injection Somatuline Altered exposure to CYP3A4 substrate Details Tacrolimus Lansoprazole Prevacid Increased tacrolimus concentration and an increased risk of toxicity Details Tacrolimus Lenacapavir Injection Sunlenca Increased sensitive P-gp/CYP3A substrate exposure and an increased risk of sensitive P-gp/CYP3A substrate-related adverse effects Details Tacrolimus Lenacapavir Oral Sunlenca Increased sensitive P-gp/CYP3A substrate exposure and an increased risk of sensitive P-gp/CYP3A substrate-related adverse effects Details Tacrolimus Lenvatinib Lenvima Increased risk of QT-interval prolongation Details Tacrolimus Letermovir Injection Prevymis Increased tacrolimus exposure and an increased risk of toxicity Details Tacrolimus Levofloxacin Levaquin Increased risk of QT interval prolongation Details Tacrolimus Levofloxacin Injection Levaquin Increased risk of QT interval prolongation Details Tacrolimus Loperamide Diamode An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Tacrolimus Losartan Arbli An increased risk of hyperkalemia Details Tacrolimus Meclofenamate Meclodium® Acute renal failure Details Tacrolimus Mefenamic Acid Ponstel® Acute renal failure Details Tacrolimus Mefloquine Lariam® An increased risk of QT interval prolongation Details

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