Tacrolimus

157 interactions 13 explained in plain English
Also sold as: Astagraf Astagraf XL® Envarsus Envarsus XR® Prograf Prograf®
About Tacrolimus

Tacrolimus is an immunosuppressant used to prevent the immune system from rejecting transplanted organs. Read the full Tacrolimus drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Tacrolimus Meloxicam Alloxate Acute renal failure Details Tacrolimus Meloxicam Injection Alloxate Acute renal failure Details Tacrolimus Metoclopramide Injection Gimoti Increased tacrolimus exposure and an increased risk of tacrolimus toxicity Details Tacrolimus Metoclopramide Nasal Spray Gimoti Increased tacrolimus exposure and an increased risk of tacrolimus toxicity Details Tacrolimus Metronidazole Flagyl Increased risk of QT-interval prolongation and arrhythmia; increased serum tacrolimus concentration and toxicity Details Tacrolimus Metronidazole Injection Flagyl Increased risk of QT-interval prolongation and arrhythmia; increased serum tacrolimus concentration and toxicity Details Tacrolimus Metronidazole Topical MetroCream® Increased risk of QT-interval prolongation and arrhythmia; increased serum tacrolimus concentration and toxicity Details Tacrolimus Metronidazole Vaginal MetroGel® Vaginal Increased risk of QT-interval prolongation and arrhythmia; increased serum tacrolimus concentration and toxicity Details Tacrolimus Mitapivat Aqvesme Increased P-gp substrate exposure; reduced CYP3A substrate exposure Details Tacrolimus Moexipril Univasc® An increased risk of hyperkalemia Details Tacrolimus Moxifloxacin Avelox Increased risk of QT interval prolongation Details Tacrolimus Moxifloxacin Injection Avelox Increased risk of QT interval prolongation Details Tacrolimus Moxifloxacin Ophthalmic Moxeza® Increased risk of QT interval prolongation Details Tacrolimus Nabumetone Relafen Acute renal failure Details Tacrolimus Nafcillin Injection Unipen® Injection Reduced tacrolimus exposure Details Tacrolimus Naproxen Aleve Acute renal failure Details Tacrolimus Neratinib Nerlynx Increased exposure to P-gp substrate and risk of toxicity Details Tacrolimus Nevirapine Viramune Reduced tacrolimus exposure Details Tacrolimus Nicardipine Cardene Increased tacrolimus exposure and an increased risk of toxicity Details Tacrolimus Nifedipine Adalat® Increased tacrolimus exposure and an increased risk of toxicity Details Tacrolimus Nimodipine Nimotop Increased tacrolimus exposure Details Tacrolimus Nisoldipine Sular Increased tacrolimus exposure Details Tacrolimus Octreotide Bynfezia An increased risk of QT interval prolongation Details Tacrolimus Octreotide Injection Bynfezia An increased risk of QT interval prolongation Details Tacrolimus Ofloxacin Floxin® An increased risk of QT interval prolongation Details Tacrolimus Ofloxacin Ophthalmic Ocuflox An increased risk of QT interval prolongation Details Tacrolimus Ofloxacin Otic Floxin® Otic An increased risk of QT interval prolongation Details Tacrolimus Olodaterol Oral Inhalation Striverdi An increased risk of QT interval prolongation and an increased risk of ventricular arrhythmias Details Tacrolimus Oxaliplatin Injection Eloxatin® Increased risk of QT-interval prolongation Details Tacrolimus Perindopril Aceon An increased risk of hyperkalemia Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.