Tezacaftor and Everolimus: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Everolimus
Tezacaftor
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased exposure to P-gp substrates and increased risk of P-gp substrates-related adverse effects
Interaction Deep Dive
Coadministration of tezacaftor with P-gp substrates having NTI increases exposure of P-gp substrates, which may increase the risk of adverse reactions related to these substrates. In a drug interaction study, concomitant use of tezacaftor 100 mg once daily and ivacaftor 150 mg twice daily with digoxin (sensitive P-gp substrate) 0.5 mg single dose resulted in increased digoxin AUC by 130% and Cmax by 132%. Monitor more frequently for adverse reactions12.
Why it happens (mechanism)
Inhibition of P-gp mediated efflux transport by tezacaftor
Literature reports
1 report — tap to read
Common questions
Can I take Tezacaftor and Everolimus together?
Increased exposure to P-gp substrates and increased risk of P-gp substrates-related adverse effects Always confirm with your pharmacist or prescriber before making any change.
How serious is the Tezacaftor and Everolimus interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
Questions for your pharmacist
- Does my dose of Tezacaftor or Everolimus need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (2)
- Product Information: ALYFTREK(R) oral tablets, vanzacaftor, tezacaftor, and deutivacaftor oral tablets. Vertex Pharmaceuticals Incorporated (per FDA), Boston, MA, 2024. DailyMed
- Product Information: TRIKAFTA(R) oral tablets oral granules, elexacaftor, tezacaftor, ivacaftor oral tablets oral granules; ivacaftor oral tablets oral granules. Vertex Pharmaceuticals Incorporated (per FDA), Boston, MA, 2024. DailyMed
Keep reading about Everolimus
Keep reading about Tezacaftor
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
Check another combination
Our instant two-drug interaction checker is almost here.
Still have questions about this combination?
Every question gets a real answer from a licensed pharmacist — free, and usually within a day.
Ask the pharmacist